:: Volume 22, Issue 3 (7-2024) ::
Int J Radiat Res 2024, 22(3): 521-527 Back to browse issues page
Acupuncture therapies on radiotherapy-induced radiation enteritis: A systematic review and meta-analysis
H. Guo , J. Zhang , H. Yang , L. Yang
Acupuncture Department, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan Province, China , yhq8206@126.com
Abstract:   (1401 Views)
Background: To assess the efficacy of various acupuncture therapies for treating radiotherapy-induced radiation enteritis (RE). Materials and Methods: Relevant studies on RE treatment through acupuncture and moxibustion were collected from medical databases. These studies were meticulously screened based on stringent inclusion and exclusion criteria. Their methodological quality was evaluated, and data were meta-analysed using Revman 5.3 software. Results: Six studies were included in this analysis. The fixed effect (FE) model revealed a statistically significant difference in the distribution of apparent efficacy between the experimental and control groups [OR = -0.18, 95% CI (-0.25, -0.11), P < 0.00001], as well as in the distribution of cure rates [OR = 0.35, 95% CI (0.20, 0.62), P = 0.0003]. The FE model also showed a significant difference in Karnofsky Performance Scale (KPS) scores [OR = -6.94, 95% CI (-10.39, -3.48), P < 0.0001]. Subgroup analysis for age and gender revealed no significant differences. Conclusion: This research model's robustness suggests that acupuncture and moxibustion, when used in combination, are more effective in treating patients with RE than control treatments. This effectiveness is evident in terms of significant effect proportion, cure rates, and KPS scores. These conclusions are consistent across different genders and ages.
Keywords: acupuncture therapy, radiation enteritis, meta-analysis, radiotherapy.
Full-Text [PDF 950 kb]   (458 Downloads)    
Type of Study: Review article | Subject: Radiation Biology
References
1. Baskar R, Lee KA, Yeo R, et al. (2012). Cancer and radiation therapy: current advances and future directions. Int J Med Sci, 9(3): 193-199. [DOI:10.7150/ijms.3635]
2. Cai Z, Cai D, Yao D, et al. (2016). Associations between body composition and nutritional assessments and biochemical markers in patients with chronic radiation enteritis: a case-control study. Nutr J, 15(1): 57. [DOI:10.1186/s12937-016-0177-6]
3. Cao DD, Xu HL, Xu M, et al. (2017). Therapeutic role of glutamine in management of radiation enteritis: a meta-analysis of 13 randomized controlled trials. Oncotarget, 8(18): 30595-30605. [DOI:10.18632/oncotarget.15741]
4. Chen HY, Li SG, Cho WC, et al. (2013). The role of acupoint stimulation as an adjunct therapy for lung cancer: a systematic review and meta-analysis. BMC Complement Altern Med, 13: 362. [DOI:10.1186/1472-6882-13-362]
5. Chou YH, Yeh ML, Huang TS, et al. (2022). Acupoint stimulation improves pain and quality of life in head and neck cancer patients with chemoradiotherapy: A randomized controlled trial. Asia Pac J Oncol Nurs, 9(1): 61-68. [DOI:10.1016/j.apjon.2021.11.002]
6. Garcia MK, Cohen L, Spano M, Spelman A, et al. (2018) Inpatient Acupuncture at a Major Cancer Center. Integr Cancer Ther, 17(1): 148-152. [DOI:10.1177/1534735416685403]
7. Hauer-Jensen M, Denham JW, Andreyev HJ (2014) Radiation enteropathy--pathogenesis, treatment and prevention. Nat Rev Gastroenterol Hepatol, 11(8): 470-479. [DOI:10.1038/nrgastro.2014.46]
8. Ho YS, Zhao FY, Yeung WF, et al. (2020). Application of Acupuncture to Attenuate Immune Responses and Oxidative Stress in Postoperative Cognitive Dysfunction: What Do We Know So Far? Oxid Med Cell Longev, 2020: 9641904. [DOI:10.1155/2020/9641904]
9. Huang J, Hwang AY M, Jia Y, Kim B, et al. (2022). Experimental Chemotherapy-Induced Mucositis: A Scoping Review Guiding the Design of Suitable Preclinical Models. Int J Mol Sci, 23(23): 15434. [DOI:10.3390/ijms232315434]
10. Li D, Chung G, Kim SK (2020). The Involvement of Central Noradrenergic Pathway in the Analgesic Effect of Bee Venom Acupuncture on Vincristine-Induced Peripheral Neuropathy in Rats. Toxins (Basel), 12(12): 775. [DOI:10.3390/toxins12120775]
11. Liang L, Shen L, Fu G, et al. (2020). Regulation of the regeneration of intestinal stem cells after irradiation. Ann Transl Med, 8(17): 1063. [DOI:10.21037/atm-20-4542]
12. Loge L, Florescu C, Alves A, et al. (2020). Radiation enteritis: Diagnostic and therapeutic issues. J Visc Surg, 157(6): 475-485. [DOI:10.1016/j.jviscsurg.2020.08.012]
13. Luo H, Chen Y, Zhang Y, et al. (2021) External treatment of traditional Chinese medicine for radiation enteritis: A protocol for systematic review and meta-analysis. Medicine (Baltimore), 100(21): e26014. [DOI:10.1097/MD.0000000000026014]
14. Qin H, Zhang H, Zhang X, et al. (2021). Resveratrol attenuates radiation enteritis through the SIRT1/FOXO3a and PI3K/AKT signaling pathways. Biochem Biophys Res Commun, 554: 199-205. [DOI:10.1016/j.bbrc.2021.03.122]
15. Rao CD, Maiya PP, Babu MA (2014). Non-diarrhoeal increased frequency of bowel movements (IFoBM-ND): enterovirus association with the symptoms in children. BMJ Open Gastroenterol, 1(1): e000011. [DOI:10.1136/bmjgast-2014-000011]
16. Schlaak RA, Frei A, Fish BL, et al. (2020). Acquired Immunity Is Not Essential for Radiation-Induced Heart Dysfunction but Exerts a Complex Impact on Injury. Cancers (Basel), 12(4): 983. [DOI:10.3390/cancers12040983]
17. Shi J, Luo D, Wan X, et al. (2023). Detecting the skewness of data from the five-number summary and its application in meta-analysis. Stat Methods Med Res, 32(7): 1338-1360. [DOI:10.1177/09622802231172043]
18. Stacey R, Green JT (2014). Radiation-induced small bowel disease: latest developments and clinical guidance. Ther Adv Chronic Dis, 5(1): 15-29. [DOI:10.1177/2040622313510730]
19. Sun J, Zhang H, Wang C, et al. (2017). Regulating the Balance of Th17/Treg via Electroacupuncture and Moxibustion: An Ulcerative Colitis Mice Model Based Study. Evid Based Complement Alternat Med, 2017: 7296353. [DOI:10.1155/2017/7296353]
20. Sung H, Ferlay J, Siegel RL, et al. (2021). Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin, 71(3): 209-249. [DOI:10.3322/caac.21660]
21. Taw MB, Nguyen CT, Wang MB (2013). Complementary and integrative treatments: rhinosinusitis. Otolaryngol Clin North Am, 46(3): 345-366. [DOI:10.1016/j.otc.2013.02.002]
22. Wang J, Hu G (2022). Nomogram to Predict Radiation Enteritis in Cervical Squamous Cell Carcinoma. Cancer Manag Res, 14: 3303-3311. [DOI:10.2147/CMAR.S383909]
23. Wang J, Lu FF, Ge MM, et al. (2023). Transcutaneous Electrical Acupoint Stimulation Improves Postoperative Sleep Quality in Patients Undergoing Laparoscopic Gastrointestinal Tumor Surgery: A Prospective, Randomized Controlled Trial. Pain Ther, 12(3): 707-722. [DOI:10.1007/s40122-023-00493-2]
24. Wąsik J, Małecka-Wojciesko E (2023). Eosinophilic Esophagitis-What Do We Know So Far? J Clin Med, 12(6): 2259. [DOI:10.3390/jcm12062259]
25. Wei QB, Ding N, Wang JJ, et al. (2020). Acupoint selection for the treatment of dry eye: A systematic review and meta-analysis of randomized controlled trials. Exp Ther Med, 19(4): 2851-2860. [DOI:10.3892/etm.2020.8561]
26. Xiao J, Li QD (2020). Multi-slice spiral CT evaluation of chronic radiation colitis and rectitis. Exp Ther Med, 20(4): 3033-3040. [DOI:10.3892/etm.2020.9069]
27. Yang Q, Qin B, Hou W, et al. (2023). Pathogenesis and therapy of radiation enteritis with gut microbiota. Front Pharmacol, 14: 1116558. [DOI:10.3389/fphar.2023.1116558]
28. Yang XF, Zheng MY, An LY, et al. (2023). Quality evaluation of guidelines for the diagnosis and treatment of radiation enteritis. Radiat Oncol, 18(1): 14. [DOI:10.1186/s13014-023-02204-9]
29. Zimmerer T, Böcker U, Wenz F, Singer MV (2008). Medical prevention and treatment of acute and chronic radiation induced enteritis--is there any proven therapy? a short review. Z Gastroenterol, 46(5): 441-448. [DOI:10.1055/s-2008-1027150]
30. Rui J, Zy C (2008) Effectiveness of acupuncture combined with drug retention enema in the treatment of distant radiation enteritis in cervical cancer. Traffic Medicine, 22(06): 711-712.
31. Ym L, Cc C (2007) Observations on the therapeutic effect of acupuncture and Emmunition in the treatment of 30 cases of radiation enteritis. Hebei Traditional Chinese Medicine (02): 149.
32. HL, Zn F, Sb Y, et al. (2013) Clinical observation on 63 cases of radiological enteritis treated with Chinese medicine retained enema combined with moxibustion. Hebei Traditional Chinese Medicine, 35(06): 815-816+819.
33. S P, Yl Z (2021) Clinical observation of mild moxibustion combined with western medicine in the treatment of radiation enteritis. Shanghai Journal of Acupuncture and Moxibustion, 40(06): 676-680.
34. T S, L H, C W, et al. (2023). Clinical effects of the empirical formula of Huangteng Combination in the treatment of radiation enteritis. Clinical Rational Use of Drugs, 16(31): 12-16.
35. Wu T (2021) Net Meta-analysis of Adverse Reactions after Radiotherapy with Different Acupuncture Therapies. (Master).
36. Lb L (2020) Clinical Observation of Warm Acupuncture and Moxibustion in the Treatment of Radiation Enteritis. (Master).
37. Y Z, L T, P Z, et al. (2023) A case report of imaging misdiagnosis of hepatic pseudolymphoma. Chinese Journal of CT and MRI, 21(12): 186-187.



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