:: Volume 1, Issue 1 (6-2003) ::
Int J Radiat Res 2003, 1(1): 37-44 Back to browse issues page
Preparation, distribution, stability and tumor imaging properties of [62Zn] bleomycin complex in normal and tumor-bearing mice
A.R. Jalilian , B. Fateh, M. Ghergherehchi, A. Karimian, M. Matlloobi
, ajalilian@nrcam.org
Abstract:   (26036 Views)

Backgrounds: Bleomycin (BLM) has been labeled with radioisotopes and widely used in therapy and diagnosis. In this study BLM was labeled with [62Zn] zinc chloride for oncologic PET studies.

Materials and methods: The complex was obtained at the pH=2 in normal saline at 90 ° C in 60 min. Radio-TLC showed an overall radiochemical yield of 95-97% (radiochemical purity > 97%). Stability of complex was checked in vitro in mice and human plasma/urine.

Results: Preliminary in vivo studies performed to determine complex stability and distribution of [62Zn] BLM in normal and fibrosarcoma-bearing mice. [62Zn] BLM accumulated significantly in induced fibrosarcoma tumors in mice according to bio-distribution/imaging studies.

Conclusion: [62Zn] BLM can be used in PET oncology studies due to its suitable physico-chemical properties as a diagnostic complex in vitro and in vivo. Further studies should be performed for evaluation of the complex behavior in higher animals. Iran . J. Radiat. Res., 2003 1(1): 37 - 44.

Keywords: PET, pharmacokinetic, biodistribution, zinc-62, bleomycin
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Type of Study: Original Research | Subject: Radiation Biology

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Volume 1, Issue 1 (6-2003) Back to browse issues page