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Disease Burden of Gynecological Tumors and radiotherapy effectiveness: A Systematic Review based on Epidemiological Insights
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X. Zhang   , J. Liu , Y. Fu |
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Abstract: (36 Views) |
Background: Gynecological cancers-including cervical, ovarian, endometrial, vulvar, vaginal, and gestational trophoblastic neoplasms-pose significant global health challenges, particularly in low- and middle-income countries (LMICs). Radiotherapy is a cornerstone of treatment, yet access remains limited in under-resourced regions, contributing to poor outcomes. This systematic review investigates the epidemiology and disease burden of gynecological cancers, focusing on incidence trends, risk factors, geographical variation, histopathological subtypes, and tumor mutational burden (TMB). It also evaluates the effectiveness of radiotherapy and the potential of personalized approaches guided by molecular profiling. Materials and Methods: A systematic search following PRISMA guidelines was conducted across PubMed, Scopus, Web of Science, and Embase for studies published between 2000 and 2023. Study quality was assessed using the QUADAS-2 tool. Results: Nine studies met the inclusion criteria. Cervical cancer showed the highest incidence, with increasing trends in some regions. High TMB was associated with aggressive histological subtypes and poorer survival, highlighting its value as a predictive biomarker. Radiotherapy significantly improved outcomes, especially when integrated into personalized treatment plans based on molecular characteristics. Conclusion: The global burden of gynecological cancers is rising, with substantial disparities in diagnosis and treatment access, especially in LMICs. Radiotherapy remains vital, but outcomes may be further improved through TMB-guided personalization. Expanding radiotherapy infrastructure and integrating molecular diagnostics are crucial for addressing global inequities and enhancing treatment efficacy. |
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| Keywords: Gynecologic neoplasms, radiotherapy, tumor mutational burden, precision medicine, uterine cervical neoplasms. |
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Full-Text [PDF 1205 kb]
(13 Downloads)
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Type of Study: Review article |
Subject:
Radiation Biology
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