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The effect of microwave radiation on osteogenesis and osteolysis of rats in the hypergravity condition and the role of Rana sylvatica Le conte oil as a radioprotector
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S. Pan   , Y.D. Yang , Y.P. Li , J.C. Wang , J.W. Zhao , Y. Wang , S.J. Lv , W.G. Pan , Z.L. Gao |
| , gaozhongli@yahoo.com.cn |
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Abstract: (10022 Views) |
| Background: Microwave Thermotherapy has
been gradually used in radiotherapy and it is reported
that microwave radiation increases bone demineralization
rate independently of temperature. Furthermore,
it becomes more and more widespread that
the damage caused by the synergistic effect of microwave
radiation and hypergravity. The experiment was
designed to investigate the effect of microwave
radiation on osteogenesis and osteolysis of rats in
the hypergravity condition and to observe the role of
Rana sylvatica Le conte oil as a radioprotector.
Materials and Methods: Wistar rats were exposed to
microwave radiation of 200mW/cm2 power density
and +6G hypergravity, and the concentrations of
osteocalcin, calcitionin, calcium, phosphorus, and
hydroxyproline and the activity of alkaline
phosphatase were detected in serum. Results: The
serum concentrations of osteocalcin and calcitionin
and the activity of alkaline phosphatase decreased,
while the calcium, phosphorus and hydroxyproline
concentrations increased after the synergistic effect
of microwave radiation and hypergravity. Rana
sylvatica Le conte oil intervention inhibited
significantly the decrease of osteocalcin concentration
and restrained significantly the increases of
hydroxyproline and calcium concentrations in serum.
Conclusion: These results imply that the synergistic
effect of microwave radiation and hypergravity
inhibits osteogenesis and enhances osteolysis in rats
causing bone metabolic disturbance, while the injury
resulted from microwave radiation and hypergravity
could be protected by intervention with Rana
sylvatica Le conte oil and it provides an original
direction in the investigation of radioprotectors. Iran.
J. Radiat. Res., 2011 9(1): 1-8 |
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| Keywords: Microwave radiation, hypergravity, osteogenesis, osteolysis, rana sylvatica Le conte oil. |
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Full-Text [PDF 262 kb]
(2347 Downloads)
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Type of Study: Original Research |
Subject:
Radiation Biology
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