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Showing 3 results for Gani
Dr. M.j. Tahmasebi Birgani, M.a. Behrooz, H. Shahbazian, A. Shams,
Volume 9, Issue 4 (3-2012)
Abstract
Background: Attenuation coefficient (μ) plays an
important role in calculations of treatment planning
systems, as well as determination of dose distributions
in external beam therapy, dosimetry, protection,
phantom materials and industry. So, its exact
measurement or calculation is very important. The
aim of this study was to evaluate the μ in different
points in the water phantom analytically as a formula,
in addition to derive and parameterize it with
dosimetry measurements data results. Materials and
Methods: To find the attenuation coefficients at each
point along the central axis of the beam in the
phantom for every size of the fields, the first mathematical
approach was performed for derivation of μs
from percentage depth dose (PDD) formula. Then by
dosimetry for different fields in different depths of
water phantom, one can parameterize the obtained
formula for μ in any field and depth. Results: By
comparing the mathematical and dosimetry results,
the parameters of the μ-expression were derived in
terms of the dimension of square field in different
depths. From this formula one can find the μ for any
field in different depths for two energies of the Varian
2100CD linear accelerator, 6, 18MV with the
statistical coefficient of determination of R2>0.98.
Conclusion: The measurement of the μ in each field
size and depth has some technical problems, but one
can easily measure the μ for every point of central
axis of the beams in any field size. Iran. J. Radiat. Res.,
2012 9(4): 251-255
H.s. Mansouri-Tehrani, M. Rabbani Khorasgani, Dr. M. Roayaei,
Volume 14, Issue 3 (7-2016)
Abstract
Background: Diarrhea is a well-recognized side effect associated with pelvic radiation; however, there is not any effective common treatment for radiation-induced diarrhea. A popular alternative is probiotics, which have been used in several gastrointestinal disorders. Probiotics are live microbial food supplements. Furthermore, honey is a putative nutritional with a variety of health effects, including antibacterial, antioxidant, anti-inflammatory and prebiotic. The present study evaluated the effects of probiotic with or without honey on radiation-induced diarrhea. Materials and Methods: Sixty-seven adult patients with pelvic cancer underwent radiotherapy for four weeks. They randomized to receive probiotic (n = 22), probiotic plus honey (n = 21) or placebo (n = 24) from one week before radiotherapy for five weeks. Diarrhea grade and stool consistency score were recorded weekly according to the Common Toxicity Criteria system and the Bristol scales, respectively. Results: The results showed a decrease in the daily number of bowel movements (p = 0.003 and 0.006), diarrhea grade (p = 0.001 and 0.001) and the need for antidiarrheal medication (p = 0.021 and 0.041) also an increase in the stool consistency (p = 0.004 and 0.005) in patients who either used probiotic or probiotic plus honey (respectively), these were significant in weeks 4 and 5 of treatment. Conclusion: Probiotics with or without honey can reduce the incidence of radiation-induced diarrhea and the need for antidiarrheal medication
M.d., G.a. Inan, I.p. Aral, H.f. Ozturk, Z. Gani, S.a. Arslan, Y. Tezcan,
Volume 21, Issue 3 (7-2023)
Abstract
Background: We aimed to investigate the relationship between the radiation dose received by the spleen and the hematological parameters of patients who underwent chemoradiotherapy after the diagnosis of locally advanced pancreatic cancer (LAPC).Materials and Methods: Patients with LAPC who were treated with chemoradiotherapy were retrospectively reviewed. Surgical status,chemoradiotherapy details, complete blood count values (baseline, mid-treatment, and end-of-treatment), mean spleen dose, and dose-volume parameters (V5, V10, V15, V20, V25, and V30) were recorded. The relationship between spleen dose-volume parameters and the development of grade 3 lymphopenia was evaluated by Spearman's rank correlation and receiver operating characteristic (ROC) analysis. Results: All dose parameters for the spleen were significantly correlated with the mid-treatment absolute lymphocyte count. In the ROC analysis, mean spleen dose (p=0.011; area under the curve [AUC]: 0.856; 95% confidence interval [CI]: 0.675-0.995), V15 (p=0.020; AUC: 0.938; 95% CI: 0.830-0.997), and V20 (p=0.002; AUC: 0.940; 95% CI: 0.811-0.1000) were significantly associated with mid-treatment grade ≥3 lymphopenia. Conclusion: A significant correlation was found between the dose received by the spleen during chemoradiotherapy in LAPC patients and the development of lymphopenia. Contouring the spleen as an organ at risk (OAR) and documenting doses is important to establish dose limitations.
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