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Showing 2 results for Lahooti
M. Najafi, Dr. H.a. Nedaie, A. Lahooti, R. Omranipour, N. Nafissi, M.e. Akbari, A. Olfatbakhsh, A. Kaviani, N. Alavi,
Volume 10, Issue 1 (6-2012)
Abstract
Background: Sentinel node biopsy (SLNB) is the
standard of care for breast cancer treatment and it is
getting wide acceptance in Iran. The radiation safety
of the procedure has been investigated under
controlled conditions, but the standard dose of radiotracer
and techniques are not always observed in the
community setting. The aim of this study was to
assess the magnitude of the absorbed doses of radiation
to the hands of operating surgeons. Materials
and Methods: Twenty consecutive SLNB procedures
were studied. Radiation dose to the hands of the
surgeons was measured by placing lithium fluoride
thermoluminescent dosimeters (TLDs) in the
surgeons' glove. The radiation dose to the abdomen
and thyroid area was measured by placing TLDs at
these areas. The injected dose of radiotracer, the
time interval to the surgery and the duration of the
surgery were recorded. Results: The injected dose of
radiotracer ranged from 0.1 to 5 mCi. The highest
absorbed dose was recorded by TLD, placed on the
non-dominant hand third finger (189.1 μSv). Mean
recorded doses were higher for non-dominant hand
second finger (53.49 ± 24.60 μSv). The measured
absorbed doses for the abdominal and thyroid area
were lower than those for the fingers. Conclusion:
This study has confirmed the procedure safety, even
with high dose of radiotracer. Nevertheless, it is
advisable to use the lowest dose of the radiotracer to
avoid the waste of resources. Iran. J. Radiat. Res.,
2012 10(1): 53-57
S.h. Mousavie Anijdan, A. Gholami, Ph.d., A. Lahooti,
Volume 18, Issue 3 (7-2020)
Abstract
Background: The main aim of this study is to radiolabel dextran coated iron oxide nanoparticles (NPs) (with 80 nm hydrodynamic size) with the Indium-111 and evaluation their biodistribution after intravenous injection normal mice. Materials and Method: The chelator Diethylenetriamine Pentaacetic Acid (DTPA) dianhydride was conjugated to SPION using a small modification of the well-known cyclic anhydride method at a ratio of 1:5 (NPs:DTPA) molar ratio. The reaction was purified with magnetic assorting columns (MACs) using high gradient magnetic field following incubation. Then the radiochemical purity of the radiolabeled NPs were determined using RTLC method. The magnetic properties of nanoparticles were measured by a 1.5 tesla clinical human MRI. Results: The NPs showed high super paramagnetic properties whereas their r2/r1 was 17.6. The RTLC showed that the purity of compound was above 99% after purification and the compound has shown a good in-vitro stability until 6 hours in the presence of human serum. The biodistribution of 111In-DTPA-NPs in mice demonstrated high uptake in the reticuloendothelial system (RES) and the blood clearance was so fast. Conclusion: Due to magnificent uptakes of this radiotracer in the liver and spleen, its stability and their fast clearance from other tissues, especially in blood, it is suggested that this radiotracer would be suitable for RES theranostics purposes.
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