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Showing 1 results for Mirna-339
L. Liang, Z. Zhang, Z. Cheng, H. Li, Ph.d., H. Jiang,
Volume 22, Issue 2 (4-2024)
Abstract
Background: MicroRNAs (miRNAs) have crucial roles in human cancers. Many studies have certified that miRNAs are implicated in tumor progression via exosomes. Nevertheless, whether miRNA-339 is derived by exosomes and its effects in gastric cancer (GC) presents obscure. Therefore, our study attempted to clarify the functional role and molecular mechanism of miRNA-339 in GC. Materials and Methods: In this research, the potential of miRNA-339 in GC was verified through miRNA-339 elevation with cell function assays. Bioinformatics analysis together with mechanical assay was implemented for assessing the regulatory relation between miRNA-339 and zinc finger protein 689 (ZNF689). Moreover, the existence of exosomes was determined via transmission electron microscopy together with nanoparticle tracking analysis. Results: miRNA-339 presented significant down-regulation in GC. miRNA-339 elevation suppressed GC cell proliferation, invasion along with migration while elevated GC cell apoptosis. miRNA-339 targeted ZNF689 3’UTR to repress ZNF689 expression, thereby hindering GC progression. Finally, miRNA-339 was majorly incorporated into exosomes to hinder GC progression. Conclusion: In summary, exosome-delivered miRNA-339 may act to be a tumor repressor in GC by targeting ZNF689, which might be an underlying therapeutic target for GC.
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