TY - JOUR JF - Int-J-Radiat-Res JO - Int J Radiat Res VL - 7 IS - 2 PY - 2009 Y1 - 2009/9/01 TI - Synthesis and radioprotective study of novel amino-alkyldithiocarbamic acid derivatives against γ-irradiation in mice TT - N2 - Background: The aim of this study was to evaluate the radioprotective capacity of some novel aminoalkylated dithiocarbamic acid potassium salts against γ-irradiation in mice. Materials and Methods: Eight compounds containing 2-aminoethyl-, 3- aminopropyl-, 4-aminobutyl-, 5-aminopentyl-, 6- aminohexyl-, 7-aminoheptyl-, 8-aminooctyl and 9- aminononyl of dithiocarbamate derivatives were prepared. Male NMRI mice were injected intraperitoneally (IP) with a geometric progression of doses (300 -1000 mg/kg), through the dose response range for lethal toxicity. To evaluate the radioprotecive activity, one-half of the toxic LD50 of each compound were injected IP to groups of twenty mice, 30 minutes prior to γ-irradiation. The treated animals were kept for 30 days, and the lethality was recorded each day. Results: Among Eight compounds of alkyl dithiocarbamic acid derivatives, 5-aminopentyl, 7-aminoheptyl, 8-aminooctyl and 9-aminononyl dithiocarbamic acid mono potassium salts are new compounds. All evaluated compounds showed a concentrationdependent effect on the survival in mice. The LD50 values were found to be more than 599 mg/kg. The percentages of 30-day survival of mice for 2- aminoethyl, 7-aminoheptyl and 8-aminooctyl dithiocarbamic acid derivatives were 7%, 40% and 13.5%, respectively, when injected 30 minutes before γ- irradiation. Other compounds had no radioprotective effects. Statistical analysis showed a significant difference between the treated and control groups for the 7-aminoheptyl derivative (p SP - 91 EP - 96 AU - Hosseinimehr, S.J. AU - Beiki, D. AU - Kebriaeezadeh, A. AU - Khalaj, A. AU - Pirali Hamedani, M. AU - Akhlaghpoor, Sh. AU - Esmaeili, H. AU - Barazesh, A.R. AD - KW - Radioprotective effect KW - aminoalkyl dithicarbamic acid KW - γ-irradiation. UR - http://ijrr.com/article-1-542-en.html ER -