TY - JOUR T1 - Protective effects of famotidine and vitamin C against radiation induced cellular damage in mouse spermatogenesis process TT - JF - Int-J-Radiat-Res JO - Int-J-Radiat-Res VL - 8 IS - 4 UR - http://ijrr.com/article-1-684-en.html Y1 - 2011 SP - 223 EP - 230 KW - Radioprotection KW - gamma-rays KW - mouse spermatogenesis KW - vitamin C KW - famotidine. N2 - Background: Radioprotective effect of famotidine was previously shown on radiation induced micronuclei and chromosomal aberrations in human peripheral lymphocytes and mouse bone marrow cells however, its radioprotective property has never been studied in mouse spermatogenesis. It was also shown that vitamin C as an antioxidant also exert its radioprotective effect on many biological systems, but in some studies no protective effect is reported. Materials and Methods: Mice were injected by small and nontoxic amount of vitamin C and famotidine (3 and 2μg) inter-testicular 2 hours before irradiating by gamma ray. 29 days after irradiation, mice were sacrificed and testes were removed, weighed and either fixed for histological study or homogenized in 1.5 mL de-ionized water and 0.5 mL SDS solution. Sperm head count was done under a light microscope. Survival fractions were calculated and plotted as a function of dose of gamma rays. Results: The sperm head count in groups treated with vitamin C and famotidine before gamma irradiation show significant increase compared to groups only irradiated by gamma rays (p M3 ER -