AU - A.R. Jalilian, AU - B. Fateh, AU - M. Ghergherehchi, AU - A. Karimian, AU - M. Matlloobi, TI - Preparation, distribution, stability and tumor imaging properties of [62Zn] bleomycin complex in normal and tumor-bearing mice PT - JOURNAL ARTICLE TA - Int-J-Radiat-Res JN - Int-J-Radiat-Res VO - 1 VI - 1 IP - 1 4099 - http://ijrr.com/article-1-6-en.html 4100 - http://ijrr.com/article-1-6-en.pdf SO - Int-J-Radiat-Res 1 AB  - Backgrounds: Bleomycin (BLM) has been labeled with radioisotopes and widely used in therapy and diagnosis. In this study BLM was labeled with [62Zn] zinc chloride for oncologic PET studies. Materials and methods: The complex was obtained at the pH=2 in normal saline at 90 ° C in 60 min. Radio-TLC showed an overall radiochemical yield of 95-97% (radiochemical purity > 97%). Stability of complex was checked in vitro in mice and human plasma/urine. Results: Preliminary in vivo studies performed to determine complex stability and distribution of [62Zn] BLM in normal and fibrosarcoma-bearing mice. [62Zn] BLM accumulated significantly in induced fibrosarcoma tumors in mice according to bio-distribution/imaging studies. Conclusion: [62Zn] BLM can be used in PET oncology studies due to its suitable physico-chemical properties as a diagnostic complex in vitro and in vivo. Further studies should be performed for evaluation of the complex behavior in higher animals. Iran . J. Radiat. Res., 2003 1(1): 37 - 44. CP - IRAN IN - Dr. A.R. Jalilian, nuclear research center for agriculture & medicine, AEOI karaj, Iran, LG - eng PB - Int-J-Radiat-Res PG - 37 PT - Original Research YR - 2003