@ARTICLE{Ansari,
author = {Mosleh-Shirazi, M.A. and Sheikholeslami, A. and Fathipour, E. and Mohammadianpanah, M. and Ansari, M. and Karbasi, S. and Hamedi, S.H. and Khanjani, N. and Sasani, M.R. and Jafari, P. and Fardid, R. and },
title = {Equivalent uniform dose and normal tissue complication probability of acute esophagitis in head-and-neck radiotherapy: Sensitivity to dose calculation accuracy},
volume = {20},
number = {2},
abstract ={Background: To quantify the influence of photon dose-calculation algorithm selection on the cervical esophagus (CE) dose indices and the derived equivalent uniform dose (EUD) and normal-tissue complication probability (NTCP) for acute esophagitis in patients with head-and-neck cancer (HNC). Materials and Methods: The Fast Photon Effective Path (FPEP) and Collapsed-Cone Convolution Superposition (CCCS) algorithms on the Prowess Panther treatment planning system were compared for 30 patients (six tumor sites). The Lyman-Kutcher-Burmann (LKB) model was used to calculate the EUDs and NTCPs. Results: On average, the more simplistic FPEP algorithm overestimated the mean dose to CE planning organ-at-risk volumes (PRVs) by 2.0% (p = 0.003). The average absolute difference in mean dose was 2.7% and the maximum difference was 9.3%. The V5Gy, V10Gy, V15Gy, V20Gy, V25Gy and V30Gy values were significantly higher with FPEP, while the point-dose and D2cc hot spots were similar. In turn, the dose differences led to an underestimation of the LKB-model prediction of the EUD by 1.4% (p = 0.297). The mean absolute difference in EUD was 4.5% and the maximum difference was 15.3%. In the 14-50 Gy mean dose range, the resulting NTCPs with FPEP were lower on average by 2.6% than CCCS (p = 0.041). Conclusions: In the group of HNC patients considered in this study, the EUD and NTCP for acute esophagitis showed to be moderately sensitive to the choice of dose-calculation algorithm. Despite an overestimated mean dose by the simpler algorithm, the NTCP underestimation, which can be large in some patients, is of clinical concern. },
URL = {http://ijrr.com/article-1-4278-en.html},
eprint = {http://ijrr.com/article-1-4278-en.pdf},
journal = {International Journal of Radiation Research},
doi = {10.52547/ijrr.20.2.28},
year = {2022}
}