%0 Journal Article %A Yu, X. %A Zhang, R. %A Cao, S. %A Cui, S. %A Liu, C. %A Wang, J. %A Cheng, X. %T Observation of the effectiveness and safety of the combination of chemotherapy and radiotherapy after the radical resection of progressive gastric cancer %J International Journal of Radiation Research %V 20 %N 1 %U http://ijrr.com/article-1-4079-en.html %R 10.52547/ijrr.20.1.17 %D 2022 %K Progressive gastric cancer, radical resection, chemotherapy, 3D-CRT, prognosis., %X Background: To analyze the effectiveness and safety of combination of 3-dimensional conformal radiotherapy (3D-CRT) and S-LOX chemotherapy after the radical resection of localized progressive gastric cancer, so as to provide the reference for clinical treatment. Materials and Methods: We enrolled 82 localized progressive gastric cancer patients undergoing the radical resection of gastric cancer, and divided them using the random digit table into two groups: 39 in the chemotherapy group received the S-LOX chemotherapy after operation, and 43 in the combination group received the 3D-CRT in combination with S-LOX chemotherapy. After treatment, we evaluated the clinical efficacy, adverse reaction, survival rate and recurrence rate of patients in two groups. Results: After 6 cycles of treatment, we found no statistical significance in difference of the objective remission rate of patients in two groups (P > 0.05), while the patients in the combination group excelled in the clinical control rate (P < 0.05). In the combination group, 2-year survival rate and survival time of patients were all higher and longer than those in the chemotherapy group (all P < 0.05), with a lower recurrence rate (P < 0.05). Furthermore, comparison of the incidence of adverse reactions of patients between two groups showed no significant difference (P > 0.05). Conclusion: After the radical resection of the localized progressive gastric cancer, 3D-CRT in combination with S-LOX chemotherapy improves the clinical control and survival of patients, while reduces the postoperative recurrence, but with no aggravation in side- or toxic-effect, thus worthy of being promoted in clinical practice. %> http://ijrr.com/article-1-4079-en.pdf %P 109-114 %& 109 %! Chemoradiotherapy in gastric cancer %9 Original Research %L A-10-2188-69 %+ Department of Radiotherapy Room, Linyi Central Hospital, Linyi, Shandong276400, China %G eng %@ 2322-3243 %[ 2022