en Radiation Biology Radiation Biology تحقيق بديع Original Research <p><strong>Background:</strong> A Boron Neutron Capture Therapy (BNCT) facility, based on a DT neutron generator, with the final goal to find out a potential, alternative, solution to existing BNCT treatment facilities which are based on nuclear reactors is examined. <strong>Materials and Methods:</strong> With the aim of the MCNP4B Monte Carlo code different beam-shaping assembly (BSA) configurations were considered. Lead was selected as reflector material while CF₂, D₂O, Fluental, PbF₄, PbF₂, BiF₃, BiF₅, MgF₂, Al₂O₃, AlF₃, TiF₃, BeD₂, CaF₂ and ⁷LiF were examined as spectrum shifters. In order to improve the quality of the beam titanium, nickel-60, iron and titanium alloy (Ti₆Al₁₄V) were simulated as fast neutrons filters while lead and bismuth were considered as gamma filters. <strong>Results:</strong> An extensive set of calculations performed with MCNP4B Monte Carlo code have shown that the combination of ⁷LiF which accommodates a conic part made of D₂O, then followed by a TiF₃ layer is the optimum moderator design. The use of three different materials for further reduction of fast neutrons, thermal neutrons and gamma rays is necessary. ⁶⁰Ni, Cd and Bi were chosen respectively for these purposes. The epithermal neutron flux obtained at the beam exit window turned out to be 3.94&times;10⁹ n cm-2 s^-1 while fulfilling all the recommended IAEA in-air Figure Of Merit (FOM) criteria. The assessment of the dose profiles in head phantom and the in-phantom FOM are also presented. <strong>Conclusion:</strong> The proposed assembly configuration may provide an attractive option for centers wishing to install a BNCT facility.</p> BNCT, DT neutron generator, epithermal neutron, MCNP 13 24 http://ijrr.com/browse.php?a_code=A-10-1-536&slc_lang=en&sid=1 J.G. Fantidis fantidis@yahoo.gr 790031947532846009381 790031947532846009381 Yes Technological Education Institute of Eastern Macedonia and Thrace A. Antoniadis 790031947532846009382 790031947532846009382 No Harvard Medical School