en Radiation Biology Radiation Biology تحقيق بديع Original Research <p dir="ltr" style="text-align: justify;"><strong>Background:</strong> &nbsp;The development of nanotechnology has been a boon to mankind as its significance paved the way for several applications in therapeutics. This study was to evaluate the anti-arthritic capability of nano Selenium-lovastatin mixture (Lov-Se) against inflammatory cascade in arthritic irradiated rats. <strong>Materials and Methods:</strong> Animal model of Arthritis was organized by subcutaneous injection of Complete Freund&rsquo;s adjuvant; CFA. Rats were exposed to &gamma;-radiation (2Gy every 3 days up to total dose of 8 Gy). Lov-Se (1ml &asymp; 20 mg kg^&minus;1 day^&minus;1Lov and 0.1 mg kg^&minus;1 day^&minus;1Se) was administrated by daily oral injection. The antioxidant parameters (heart glutathione peroxides; GSH-Px, catalase; CAT, superoxide dismutase; SOD, xanthine dehydrogenase; XDH, reduced glutathione; GSH and blood selenium; Se), oxidant markers (heart Xanthine oxidase; XO, Nitric oxide; NO, protein carbonyls and thiobarbituric acid reactive substances; TBARS) and the inflammatory molecules (serum tumor necrosis factor-alpha TNF-&alpha;, C-reactive protein; CRP and rheumatoid factor; RF) were determined. <strong>Results:</strong> The arthritic and arthritic irradiated rats were displayed augment oxidative stress, inflammatory cascade and impaired antioxidant status compared to control. <strong>Conclusion:</strong> The data revealed that Lov-Se administration ameliorate oxidative, antioxidants parameters as well as inflammatory factors. The prolonged administration of Lov-Se mixture in appropriate concentration could exert a considerable systemic anti-inflammatory action through adjustment of red-ox tone and the integration of XDH/XO ratio.</p> <p></p> Arthritis, γ-radiation, nano selenium-lovastatin, antioxidant, oxidative stress, inflammation 305 316 http://ijrr.com/browse.php?a_code=A-10-1-577&slc_lang=en&sid=1 Khaled Sh. Azab khshazab@hotmail.com 790031947532846007615 790031947532846007615 Yes Atomic Energy Authority N.M. Thabet 790031947532846007616 790031947532846007616 No National Center for Radiation Research and Technology A.R.B. Abdel Ghaffar 790031947532846007617 790031947532846007617 No Biochemistry Department, Faculty of Science A. Osman 790031947532846007618 790031947532846007618 No Biochemistry Department, Faculty of Science A.I. El-Batal 790031947532846007619 790031947532846007619 No National Center for Radiation Research and Technology