International Journal of Radiation Research
نشریه پرتو پژوه
Int J Radiat Res
Basic Sciences
http://ijrr.com
79
journal79
2322-3243
2345-4229
10.61186/ijrr
en
jalali
1395
4
1
gregorian
2016
7
1
14
3
online
1
fulltext
en
Effects of Probiotics with or without Honey on Radiation-induced Diarrhea
Radiation Biology
Radiation Biology
تحقيق بديع
Original Research
<p style="text-align: justify;"><strong>Background:</strong> Diarrhea is a well-recognized side effect associated with pelvic radiation; however, there is not any effective common treatment for radiation-induced diarrhea. A popular alternative is probiotics, which have been used in several gastrointestinal disorders. Probiotics are live microbial food supplements. Furthermore, honey is a putative nutritional with a variety of health effects, including antibacterial, antioxidant, anti-inflammatory and prebiotic. The present study evaluated the effects of probiotic with or without honey on radiation-induced diarrhea. <strong>Materials and Methods:</strong> Sixty-seven adult patients with pelvic cancer underwent radiotherapy for four weeks. They randomized to receive probiotic (n = 22), probiotic plus honey (n = 21) or placebo (n = 24) from one week before radiotherapy for five weeks. Diarrhea grade and stool consistency score were recorded weekly according to the Common Toxicity Criteria system and the Bristol scales, respectively. <strong>Results</strong>: The results showed a decrease in the daily number of bowel movements (p = 0.003 and 0.006), diarrhea grade (p = 0.001 and 0.001) and the need for antidiarrheal medication (p = 0.021 and 0.041) also an increase in the stool consistency (p = 0.004 and 0.005) in patients who either used probiotic or probiotic plus honey (respectively), these were significant in weeks 4 and 5 of treatment. <strong>Conclusion:</strong> Probiotics with or without honey can reduce the incidence of radiation-induced diarrhea and the need for antidiarrheal medication</p>
<p></p>
Probiotics, honey, diarrhea, radiotherapy, pelvic cancer.
205
213
http://ijrr.com/browse.php?a_code=A-10-1-620&slc_lang=en&sid=1
H.s.
Mansouri-Tehrani
790031947532846007968
790031947532846007968
No
Department of Biotechnology
M.
Rabbani Khorasgani
790031947532846007969
790031947532846007969
No
Department of Biology
M.
Roayaei
Roayaei@med.mui.ac.ir
790031947532846007970
790031947532846007970
Yes
Department of Radiation Oncology