en Medical Physics Medical Physics تحقيق بديع Original Research <p align="center"> <strong> ABSTRACT </strong></p><p> <strong>Background: </strong>The brain response to temporal frequencies (TF) has been already reported, but with no study reported for different TF with respect to various spatial frequencies (SF). </p><p> <strong>Materials and Methods:</strong> fMRI was performed by 1.5T GE-system in 14 volunteers during checkerboard, with TFs of 4, 6, 8 and 10Hz in low and high SFs of 0.5 and 8cpd. </p><p> <strong>Results:</strong> Average percentage BOLD signal change demonstrated the amplitude of the fMRI response to different TFs was maximal in 6Hz for high SF of 8cpd, while, it was maximal at TF of 8Hz for low SF of 0.5cpd. </p><p> <strong>Conclusion:</strong> The results are useful for vision therapy (such as the treatment of <i>Amblyopia</i>) and visual task selecting in fMRI studies<strong>.</strong></p> ,Spatial frequency,cortical response,, temporal frequency,human,fMRI 191 194 http://ijrr.com/browse.php?a_code=A-10-1-176&slc_lang=en&sid=1 A. Mirzajani mirzajani@sina.tums.ac.ir 79003194753284600485 79003194753284600485 Yes N. Riyahi-Alam 79003194753284600486 79003194753284600486 No M.A. Oghabian 79003194753284600487 79003194753284600487 No K. Firuznia 79003194753284600488 79003194753284600488 No H. Saberi 79003194753284600489 79003194753284600489 No