en Radiation Biology Radiation Biology مطالعه موردي Case Report <div style="text-align: justify;">Background: Exposure to&nbsp;ionizing&nbsp;radiation is known to have various effects on hematological parameters of&nbsp;biological&nbsp;sample. This study was aimed at evaluating the effect of&nbsp;ionizing&nbsp;radiation on some hematological parameters in guinea pigs. Materials and Methods: Thirty-six (36) apparently healthy adult guinea pigs of both sexes weighing between 700g &ndash; 1200g were used in the present study. The guinea pigs were&nbsp;categorized&nbsp;into three groups, 12 per group; group A (control), group B, and C were exposed to X-rays within the diagnostic range, using 70 kV and 12.5mAs; using X-ray machine MS-185, serial no. 0904 GE at a source to skin distance (SSD) of 90cm.&nbsp;Blood samples were collected from all the guinea pigs at intervals of 1 hour, 24 hours 72 hours, 168 hours and 336 hours post-irradiation, and subjected to standard hematological analysis.&nbsp; Results: A continuous decline in the mean total white blood cell count and mean lymphocyte, monocyte, neutrophil and eosinophil count after 1hour in both groups was observed, and more pronounced after 24 hours post-irradiation. However, stability was observed 72 hours post-irradiation in both groups. Conclusion: This study found a depleting effect of low dose&nbsp;ionizing&nbsp;radiation on white blood cell count, with appreciable recovery occurring after 72 hours onward.&nbsp;</div> White blood cells, irradiation, Guinea pigs, ionizing radiation, hematological parameters. 129 132 http://ijrr.com/browse.php?a_code=A-10-1-711&slc_lang=en&sid=1 G. Luntsi geostuffy@unimaid.edu.ng 7900319475328460015637 7900319475328460015637 Yes Department of Medical Radiography, College of Medical Sciences, University of Maidugri, Borno State, North-eastern Nigeria V.S. Daniel 7900319475328460015638 7900319475328460015638 No Department of Medical Radiography, College of Medical Sciences, University of Maidugri, Borno State, North-eastern Nigeria B.T. Paul 7900319475328460015639 7900319475328460015639 No Veterinary Teaching Hospital, University of Maiduguri, Borno State, North-eastern Nigeria I.C. Nwobi 7900319475328460015640 7900319475328460015640 No Department of Medical Radiography, College of Medical Sciences, University of Maidugri, Borno State, North-eastern Nigeria A.M. Abdullahi 7900319475328460015641 7900319475328460015641 No Veterinary Teaching Hospital, University of Maiduguri, Borno State, North-eastern Nigeria M.S. Ahmadu 7900319475328460015642 7900319475328460015642 No Department of Radiology, University of Maiduguri Teaching Hospital, Borno State, North-eastern Nigeria A.D. Obotiba 7900319475328460015643 7900319475328460015643 No Department of Medical Radiography, College of Medical Sciences, University of Maidugri, Borno State, North-eastern Nigeria F.B. Nkubli 7900319475328460015644 7900319475328460015644 No Department of Medical Radiography, College of Medical Sciences, University of Maidugri, Borno State, North-eastern Nigeria