International Journal of Radiation Research
نشریه پرتو پژوه
Int J Radiat Res
Basic Sciences
http://ijrr.com
79
journal79
2322-3243
2345-4229
10.61186/ijrr
en
jalali
1382
9
1
gregorian
2003
12
1
1
3
online
1
fulltext
en
[66Ga]Oxine complex preparation and stability as a possible PET radiopharmaceutical.
Radiation Biology
Radiation Biology
تحقيق بديع
Original Research
<p><strong>Background: </strong>Gallium-66 (T<sub>1/2</sub>= 9.49 h) is an interesting radionuclide that has potential for positron emission tomography (PET) imaging of biological processes in intermediate to slow target tissue uptake. Oxine has been labeled with this radioisotope in the form of [<sup>66</sup>Ga]gallium chloride for its possible diagnostic properties. </p><p><strong>Materials and methods: </strong><sup>66</sup>Ga was produced in the 30 MeV cyclotron (Cyclon-30, IBA) via the <sup>66</sup>Zn(p,n)<sup>66</sup>Ga reaction.TLC was performed on polymer backed silica gel. A Gamma spectrometer HPGe detector was used for countings. </p><p><strong>Results: </strong>After the bombardment, the production yield was 11.2 mCi/ m Ah. The [<sup>66</sup>Ga]Oxine complex was obtained at the pH=5 in phosphate buffer medium at 37 ° C in 10 minutes. Radio-TLC showed an overall radiochemical yield of 97% (radiochemical purity > 98%). The chemical stability of the complex was checked <i>in vitro </i>with a specific activity of 896 mCi/ml. </p><p><strong>Conclusion: </strong>[<sup>66</sup>Ga]oxine can be used in diagnostic studies due to its suitable physico-chemical properties both <i>in vitro</i> and <i>in</i> <i>vivo</i>. <i>Iran </i><i>. J. Radiat. Res., 2003 1(3): 157 - 161 </i></p>
, oxine, positron emission tomography (PET), blood cell labeling, stability
157
161
http://ijrr.com/browse.php?a_code=A-10-1-23&slc_lang=en&sid=1
A. R. Jalilian
7900319475328460062
7900319475328460062
Yes
P. Rowshanfarzad
7900319475328460063
7900319475328460063
No
A. Rahiminejad
7900319475328460064
7900319475328460064
No
A.A. Rajamand
7900319475328460065
7900319475328460065
No
A. J. Novinrooz
7900319475328460066
7900319475328460066
No