International Journal of Radiation Research
نشریه پرتو پژوه
Int J Radiat Res
Basic Sciences
http://ijrr.com
79
journal79
2322-3243
2345-4229
10.61186/ijrr
en
jalali
1397
7
1
gregorian
2018
10
1
16
4
online
1
fulltext
en
Pharmacokinetic studies and human absorbed dose estimation of 68Ga-(4 {[(bis (phosphonomethyl)) carbamoyl] methyl}-7,10-bis(carboxymethy l) -1,4,7,10-tetraazacyclododec-1-yl) acetic acid
Radiation Biology
Radiation Biology
تحقيق بديع
Original Research
<div style="text-align: justify;">Background: In this study, human absorbed dose of a newly introduced bone imaging agent, 68Ga-(4-{[(bis(phosphonomethyl))carbamoyl]methyl}-7,10-bis(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl) acetic acid (68Ga-BPAMD), was estimated based on the rats data. Materials and Methods: <sup>68</sup>Ga was obtained from the <sup>68</sup>Ge/<sup>68</sup>Ga generator and it's radionuclidic and radiochemical purities were investigated. <sup>68</sup>Ga-BPAMD complex was prepared at optimal conditions and the radiochemical purity was studied using instant thin layer chromatography (ITLC) method. The final preparation was injected to the normal rats and the biodistribution of the complex was followed up to 120 min post injection. The accumulated activity for animal organs was calculated. Finally, the human absorbed dose of the complexes was estimated by RADAR method. Results: <sup>68</sup>Ga-BPAMD complex was prepared in high radiochemical purity (>99%, ITLC) at optimal conditions. The biodistribution of the complex demonstrated that the main remained radioactivity would considerably accumulate into the bones. The results showed the highest amounts of absorbed dose on the bone surface (0.253 mGy/MBq) and in the bone marrow (0.250 mGy/MBq), while the other organs would receive an insignificant absorbed dose after injection of the<sup> 68</sup>Ga-BPAMD complex. Conclusion: The comparison of dosimetric results for <sup>68</sup>Ga-BPAMD with other complexes shows this complex is a safer agent for bone scanning. This property as well as other characteristics such as the high resolution images of the positron emission tomography (PET) scanning and the availability of <sup>68</sup>Ga in the form of <sup>68</sup>Ge/<sup>68</sup>Ga generator, make this complex as a suitable agent for PET bone imaging.</div>
Absorbed dose, Bone metastases, BPAMD, Ga-68, Positron emission tomography.
473
480
http://ijrr.com/browse.php?a_code=A-10-1-746&slc_lang=en&sid=1
A.
Rabiei
7900319475328460012273
7900319475328460012273
No
Department of Energy Engineering and Physics, Amir Kabir University of Technology, Tehran, Iran
M.
Shamsaei
7900319475328460012274
7900319475328460012274
No
Department of Energy Engineering and Physics, Amir Kabir University of Technology, Tehran, Iran
H.
Yousefnia
hyousefnia@aeoi.org.ir
7900319475328460012275
7900319475328460012275
Yes
Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran
A.R.
Jalilian
7900319475328460012276
7900319475328460012276
No
Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran