en Radiation Biology Radiation Biology گزارش کوتاه Short Report <div style="text-align: justify;">Background: Post-operative fibrosis related pains and functional anomalies&nbsp; can be serious problems for patients. Radiotherapy (RT) could inhibit fibrosis which may occurs post- operation especially following laminectomy. Therefore, this study was designed to investigate the effect of peri-operative RT on the prevention of post-operative fibrosis and scar formation on rats. Materials and Methods: Twenty three male Wistar albino rats,&nbsp; were divided into three experimental groups. Laminectomy was performed to L3 and L4 lomber vertebral regions of group L and L+R rats. The rats in L+R group&nbsp; in addition to this procedure also received peri-operative RT on the laminectomy area. A total dose of 700 cGy of RT was applied as a single fraction&nbsp; using electrons. Control rats received no treatment. A rotarod test was performed at 20, 30 and 40 rpm/min speed rates to determine the physical performances of the rats. Results: The results have indicated statistically significant (P<0.05) differences for the 30 rpm/min rotarod test between the L and L+R groups. Histopatologically, significant differences were observed in epidural fibrosis, fibroblast cell density and arachnoid adhesion between the L and L+R groups. Conclusion: It was concluded that peri-operative RT may provide a significant advantage for prevention post-laminectomic of scar tissue formation.</div> Laminectomy, peri-operative radiotherapy, fibrosis, rotarod tests. 481 485 http://ijrr.com/browse.php?a_code=A-10-1-747&slc_lang=en&sid=1 H.S. Kiziltan 7900319475328460012278 7900319475328460012278 No Department of Radiation Oncology, Bezmialem Vakif University, Faculty of Medical, 34093 Fatih, Istanbul, Turkey A.H. Eris 7900319475328460012279 7900319475328460012279 No Department of Radiation Oncology, Bezmialem Vakif University, Faculty of Medical, 34093 Fatih, Istanbul, Turkey I. Meral 7900319475328460012280 7900319475328460012280 No Department of Physiology, Faculty of Medical, Bezmialem Vakif University, 34093 Fatih, Istanbul, Turkey H. Seyithanoglu 7900319475328460012281 7900319475328460012281 No Department of Neurosurgery, Bezmialem Vakif University 34093 Faculty of Medical, Fatih, Istanbul, Turkey T. Dundar 7900319475328460012282 7900319475328460012282 No Department of Neurosurgery, Bezmialem Vakif University 34093 Faculty of Medical, Fatih, Istanbul, Turkey F. Eren 7900319475328460012283 7900319475328460012283 No Department of Physical Therapy and Rehabilitation, Bezmialem Vakif University, Faculty of Medical, 34093 Fatih, Istanbul, Turkey N. Unver 7900319475328460012284 7900319475328460012284 No Department of Pathology, Bezmialem Vakif University, Faculty of Medical, 34093 Fatih, Istanbul, Turkey T. Aydin 7900319475328460012285 7900319475328460012285 No Department of Physical Therapy and Rehabilitation, Bezmialem Vakif University, Faculty of Medical, 34093 Fatih, Istanbul, Turkey A. Mayadagli alpdag@hotmail.com 7900319475328460012286 7900319475328460012286 Yes Department of Radiation Oncology, Bezmialem Vakif University, Faculty of Medical, 34093 Fatih, Istanbul, Turkey A.G. Bayir 7900319475328460012287 7900319475328460012287 No Department of Nutrition and Dietetics, Bezmialem Vakif University Faculty of Medical, 34093 Fatih, Istanbul, Turkey M. Celikten 7900319475328460012288 7900319475328460012288 No Department of Animal Scientific Research Center, Bezmialem Vakif University Medical Faculty 34093 Fatih, Istanbul, Turkey