International Journal of Radiation Research
نشریه پرتو پژوه
Int J Radiat Res
Basic Sciences
http://ijrr.com
79
journal79
2322-3243
2345-4229
10.61186/ijrr
en
jalali
1397
10
1
gregorian
2019
1
1
17
1
online
1
fulltext
en
Effects of N-acetylcysteine on life shortening induced by chronic low dose-rate gamma-ray exposure in mice
Radiation Biology
Radiation Biology
تحقيق بديع
Original Research
<div style="text-align: justify;">Background: The development of methods to alleviate radiation-induced health effects is important for the practical use of radiation therapy and for understanding the molecular mechanisms mediating these effects. Here, we examined the protective capability of N-acetylcysteine (NAC) on life-shortening effects induced by continuous low dose-rate gamma-ray exposure in mice. Materials and Methods: Female B6C3F1 mice were exposed to gamma-rays for 400 days at a dose rate of 20 mGy/day beginning at 8 weeks of age. Control unexposed mice and exposed mice were divided into two groups; the first was provided with regular water, and the second was administered 40 mM NAC during the exposure period. Results: Although NAC administration did not affect the life span of non-irradiated mice (p = 0.232), a 59-days life extension was observed in the exposed group (p = 0.0177). Moreover, radiation exposure and NAC treatment affected body weight. The reduction of body weight observed in NAC treated mice was associated with a reduction in water intake. Conclusion: Our data demonstrated that the life-shortening effects of chronic low dose-rate radiation exposure in mice were alleviated by NAC administration.</div>
low dose-rate radiation, chronic exposure, life-shortening effect, N-acetylcysteine, mouse model.
67
73
http://ijrr.com/browse.php?a_code=A-10-1-759&slc_lang=en&sid=1
K.
Yamauchi
yamauchi@ies.or.jp
7900319475328460012689
7900319475328460012689
Yes
Department of Radiobiology, Institute for Environmental Sciences, 2-121, Hacchazawa, Takahoko, Rokkasho, Kamikita, Aomori 039-3213, Japan
Y.
Tsutsumi
7900319475328460012690
7900319475328460012690
No
Tohoku Environmental Science Service Corporation, 330-2, Noduki, Obuchi, Rokkasho, Kamikita, Aomori 035-0071, Japan
K.
Ichinohe
7900319475328460012691
7900319475328460012691
No
Department of Radiobiology, Institute for Environmental Sciences, 2-121, Hacchazawa, Takahoko, Rokkasho, Kamikita, Aomori 039-3213, Japan
M.
Yoneya
7900319475328460012692
7900319475328460012692
No
Department of Radiobiology, Institute for Environmental Sciences, 2-121, Hacchazawa, Takahoko, Rokkasho, Kamikita, Aomori 039-3213, Japan
J.I.
Komura
7900319475328460012693
7900319475328460012693
No
Department of Radiobiology, Institute for Environmental Sciences, 2-121, Hacchazawa, Takahoko, Rokkasho, Kamikita, Aomori 039-3213, Japan
T.
Ono
7900319475328460012694
7900319475328460012694
No
Department of Radiobiology, Institute for Environmental Sciences, 2-121, Hacchazawa, Takahoko, Rokkasho, Kamikita, Aomori 039-3213, Japan
K.
Tanaka
7900319475328460012695
7900319475328460012695
No
Department of Radiobiology, Institute for Environmental Sciences, 2-121, Hacchazawa, Takahoko, Rokkasho, Kamikita, Aomori 039-3213, Japan