International Journal of Radiation Research
نشریه پرتو پژوه
Int J Radiat Res
Basic Sciences
http://ijrr.com
79
journal79
2322-3243
2345-4229
10.61186/ijrr
en
jalali
1397
10
1
gregorian
2019
1
1
17
1
online
1
fulltext
en
Influence of different treatment planning techniques on radiation doses to the heart, left anterior descending coronary artery and left lung in the radiotherapy of left-sided breast cancer patients
Radiation Biology
Radiation Biology
تحقيق بديع
Original Research
<div style="text-align: justify;">Background: Breast-conserving surgery (BCS) followed by radiotherapy (RT) is the standard of care for women with breast cancer. Evidence shows that RT dose to the heart can result in ischemic heart disease. In this study we compared 3 different RT techniques were for heart, left anterior descending coronary artery (LAD) and lung doses in left breast cancer patients after breast-conserving surgery. Materials and Methods: Three different plans were designed for each patient using conventional tangential fields, 6+18 MV combination beams, and field-in-field (FIF) technique. These were compared in terms of doses to the planning target volume (PTV), ipsilateral lung, heart and LAD. Results: Forty left breast cancer patients were included in this study. Mean PTV V95% was 95.74% for conventional, 90.45% for FIF and 87.89% for 6+18 MV combination beams (p<0.05). Mean left lung dose was 11.22 Gy for FIF, 12.25 Gy for 6+18 MV and 12.95 Gy for conventional technique (p<0.05). Mean heart dose was 4.52 Gy for FIF, 4.85 Gy for 6+18 MV and 5.13 Gy for conventional technique (p<0.05), and mean D2% for LAD was 40.06, 43.43 and 45.25 Gy (p<0.01) in FIF, 6+18 MV and conventional techniques, respectively.<br>
Conclusion: These results indicated that FIF and 6+18 MV combination techniques significantly reduced the doses received by the heart, LAD and left lung compared to conventional tangential fields, while FIF was superior to 6+18 MV considering the above-mentioned variables. The lower doses to the organs at risk were achieved with a small but statistically significant loss in PTV coverage.</div>
Left breast cancer, radiotherapy, heart dose, coronary artery dose, tangential fields, field-in-field technique.
119
125
http://ijrr.com/browse.php?a_code=A-10-1-764&slc_lang=en&sid=1
P.
Haddad
7900319475328460013211
7900319475328460013211
No
Radiation Oncology Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
F.
Hadjilooei
7900319475328460013212
7900319475328460013212
No
Department of Radiation Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
H.A.
Nedaei
7900319475328460013213
7900319475328460013213
No
Radiation Oncology Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
B.
Kalaghchi
kalaghchi@tums.ac.ir
7900319475328460013214
7900319475328460013214
Yes
Radiation Oncology Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
F.
Amouzgar Hashemi
7900319475328460013215
7900319475328460013215
No
Radiation Oncology Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
F.
Farhan
7900319475328460013216
7900319475328460013216
No
Department of Radiation Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
M.
Babaei
7900319475328460013217
7900319475328460013217
No
Department of Radiation Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
M.
Esfahani
7900319475328460013218
7900319475328460013218
No
Department of Radiotherapy Physics, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
Sh.
Shahriarian
7900319475328460013219
7900319475328460013219
No
Department of Radiology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran