en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: Hearing loss is a major concern in the patient with head and neck cancer (HNC) undergoing radiotherapy (RT) and/or chemotherapy (CHT). The present study aimed to assess the incidence of sensorineural hearing loss (SNHL) at 6 months follow-up after RT and/or concurrent Cisplatin-based CHT.&nbsp; Materials and Methods: In this prospective study, 60 patients with histopathologically proven HNC underwent three-dimensional conformal radiotherapy (3DCRT) (35 patients) and concurrent Cisplatin-based CHT and RT (25 patients). The status of the hearing was assessed pre-treatment (baseline), one day, 1, 3 and 6 months after treatment by pure tone audiometry (PTA) and other audiometric tests such as tympanometry (TM), acoustic reflex (AR), and speech audiometry (SA). Results: In the RT group, SNHL was observed in 18 patients and hearing loss occurred in 47 % (33 of 70 ears) of ears. In the chemo-radiotherapy (CRT) group, SNHL was discerned in 20 patients and hearing loss appeared in 88 % (44 of 50 ears) of ears. Perforation of the tympanic membrane occurred in 2/35 patients in the RT group and 1/25 patients in the CRT group. The AR threshold (ART) of patients with CRT significantly increased compared to the RT group at the end of 6 months after treatment (P <0.05). Meanwhile, there was a significant difference in the speech discrimination score (SDS) and speech recognition threshold (SRT) between the CRT group and RT group at the 6 months after treatment (P <0.05). Conclusion: The incidence of hearing loss in patients that underwent CRT was higher. The auditory system should be considered as a critical organ at risk (OAR) in treatment planning.</div> Sensorineural hearing loss, head and neck cancer, radiotherapy, cisplatin-based chemotherapy. 633 641 http://ijrr.com/browse.php?a_code=A-10-1-826&slc_lang=en&sid=1 A.H. Rezaeyan 7900319475328460014023 7900319475328460014023 No Department of Medical Physics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran H. Ghaffari 7900319475328460014024 7900319475328460014024 No Department of Medical Physics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran S.R. Mahdavi 7900319475328460014025 7900319475328460014025 No Department of Medical Physics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran A.R. Nikoofar 7900319475328460014026 7900319475328460014026 No Department of Radiation Oncology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran M. Najafi 7900319475328460014027 7900319475328460014027 No Radiology and Nuclear Medicine Department, School of Paramedical Sciences, Kermanshah University of Medical Science, Kermanshah, Iran F. Koosha 7900319475328460014028 7900319475328460014028 No Radiology Technology Department, Allied Medicine Faculty, Shahid Beheshti University of Medical Sciences, Tehran, Iran S. Cheraghi Cheraghi cheraghi.s@iums.ac.ir 7900319475328460014029 7900319475328460014029 Yes Radiation Biology Research Center, Iran University of Medical Sciences, Tehran, Iran