en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: Physical agents, such as ultrasound, can promote functional restoration and regenerative processes of the peripheral nervous system. However, little is known about the effects of X-ray radiation on nerve&nbsp;regeneration after peripheral nerve injury. The aim of the present study was to investigate the effects of various doses of X-ray radiation on nerve&nbsp;regeneration after sciatic nerve injury in rats. Materials and Methods: The sciatic nerves of Sprague-Dawley rats were transected and repaired via epineurium end-to-end neurorrhaphy. Eighty rats each received single and local X-ray doses of 0 Gy, 0.2 Gy, 1 Gy, 7 Gy and 14 Gy. Functional and morphological assessments of the process of nerve regeneration were performed by using various measurement tools. Results: Compared with the 0 Gy, 0.2 Gy and 14 Gy groups, the 1 Gy and 7 Gy radiation groups experienced significantly increased sciatic functional index, motor nerve conductive velocity (MNCV), expression of S-100, mean diameter of axons, and thickness of myelin sheaths and decreased perineural scar tissue. There were no differences between the 1 Gy group and the 7 Gy group or between the 0 Gy group, the 0.2 Gy group and the 14 Gy group with the exception of MNCV and the expression level of S-100. Conclusion: X-ray radiation in doses of 1 Gy and 7 Gy promoted nerve regeneration after sciatic nerve injury in a rat model. The dose of 14 Gy exerted inhibitory effects, and 0.2 Gy exerted no significant effect on nerve regeneration.</div> Peripheral nerve injury, nerve regeneration, X-ray irradiation. 23 31 http://ijrr.com/browse.php?a_code=A-10-1-836&slc_lang=en&sid=1 Y. Zhang 7900319475328460015374 7900319475328460015374 No Department of Hand and Foot Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China B. Jiang 7900319475328460015375 7900319475328460015375 No Department of Hand and Foot Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China J.J. Zhao 7900319475328460015376 7900319475328460015376 No Department of Hand and Foot Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China J.P. Zhou 7900319475328460015377 7900319475328460015377 No Department of Hand and Foot Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China Z.C. Zuo 7900319475328460015378 7900319475328460015378 No Department of Hand and Foot Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China Z.Y. Qian 13625280020@163.com 7900319475328460015379 7900319475328460015379 No Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China P.J. Wang wangpeiji88 7900319475328460015380 7900319475328460015380 Yes Department of Hand and Foot Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China