International Journal of Radiation Research
نشریه پرتو پژوه
Int J Radiat Res
Basic Sciences
http://ijrr.com
79
journal79
2322-3243
2345-4229
10.61186/ijrr
en
jalali
1398
10
1
gregorian
2020
1
1
18
1
online
1
fulltext
en
Radioprotective efficacy of ginger (Zingiber officinale) extract against gamma-ray radiation-induced genotoxicity in rats
Radiation Biology
Radiation Biology
تحقيق بديع
Original Research
<div style="text-align: justify;">Background: Ginger (Zingiber officinale), a member of the Zingiberaceae family that contains phenolic compounds such as gingerol, paradol, zingerone, zingiberol and shogaols, has antioxidant, anti-inflammatory, antimicrobial, antifungal and antitumour activity. Materials: The present investigation was intended to evaluate the radioprotective effects of ginger extract in Wistar albino rats against whole-body gamma-ray irradiation. Rats were orally administered 250 mg/kg b.w. of ginger extract by gavage for 14 consecutive days. On the 14<sup>th</sup> day, 2 hr after the last ginger administration, the animals were exposed to whole-body gamma-rays of 6 Gy. The radioprotective potential of ginger was assessed through measurement of the DNA oxidative stress marker 8-hydroxy-2’-deoxyguanosine in serum, analysis of chromosomal abnormalities and micronucleus formation in bone marrow cells and estimation of DNA impairment in both bone marrow cells and epidydimal sperm using comet assay. Sperm DNA integrity and sperm shape abnormalities were also studied. Results: The results revealed that ginger extract reduced DNA oxidation by restoring the levels of 8-hydroxy-2’-deoxyguanosine in serum. Ginger also significantly reduced radiation-induced chromosomal abnormality and micronucleus formation. Additionally, pretreatment with ginger extract significantly decreased DNA damage in both bone marrow cells and epididymal sperm, maintained sperm DNA integrity and reduced the occurrence of sperm anomalies after irradiation. Conclusion: Our results confirmed that ginger extract offers rats significant protection against whole-body gamma-rays and helps to alleviate the effects of radiation. Our findings suggest a new strategy to combat the effects of acute radiation doses that impair biological systems.</div>
Ginger, gamma-radiation, DNA damage, genotoxicity.
43
55
http://ijrr.com/browse.php?a_code=A-10-1-838&slc_lang=en&sid=1
D.D.
Abd El-Monem
7900319475328460015386
7900319475328460015386
No
Department of Zoology, Faculty of Women for Arts, Science and Education, Ain Shams University, Cairo, Egypt
S.H.B.
Elwakeel
sherien.elwakeel@women.asu.edu.eg
7900319475328460015387
7900319475328460015387
Yes
Department of Zoology, Faculty of Women for Arts, Science and Education, Ain Shams University, Cairo, Egypt