en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">ABSTRACT: Radiofrequency electromagnetic radiation (RF-EMR) of mobile phone has adverse effects on human health, such as the liver tissue. Melatonin, as a neurohormone has antioxidant property. The aim of present study was to evaluate the protective effects of melatonin on liver damage induced by mobile phone-radiofrequency radiation. Matherials and Methods: In this experimental study, 32 adult male BALB/c mice were divided randomly into four groups: control group (received only normal saline), melatonin group (2 mg/kg, for 30 consecutive days, intraperitoneally), Electromagnetic radiofrequency radiations (RF-EMR) group (4 hours per day for 30 consecutive days, whole body), and melatonin + RF-EMR) group (melatonin was prescribed one hour before exposure to RF-EMR. One day after treatment period were evaluated oxidative stress parameters, serum biochemical, and histopathological assays of liver. Results: The results exhibited that RF-EMR significantly increased oxidative stress (increased Malondialdehyde and decreased Glutathione level) compared with control and melatonin group (P < 0.001). Histopathological findings in the RF-EMR group showed periportal leucocyte infiltration, dilation of sinusoids, necrosis, vacuolation, and granulomatous formation. Also, alanine transaminase and aspartate transaminase,&nbsp;alkaline phosphatase&nbsp;in serum increased significantly compared with control and melatonin groups (P<0.001). Melatonin administration significantly reduced oxidative stress (P<0.01) in the radiated mice and ameliorated histopathological compared with control group. Conclusion: The data indicate that RF-EMR induces oxidative damage and changes histopathological structure in the liver. Melatonin decreased oxidative stress and improved the liver damage induced by RF-EMR.</div> Radiofrequency electromagnetic radiation, hepatotoxicity, oxidative stress, antioxidant, melatonin. 133 141 http://ijrr.com/browse.php?a_code=A-10-1-848&slc_lang=en&sid=1 R. Moradpour 7900319475328460015670 7900319475328460015670 Yes Department of Biomedical Engineering, Rouzbahan Institute of Higher Education, Sari, Iran M. Shokri 7900319475328460015671 7900319475328460015671 No Department of Anatomy, Faculty of Medicine, Molecular and Cell Biology Research Center, Mazandaran University of Medical Sciences, Sari, Iran S. Abedian 7900319475328460015672 7900319475328460015672 No Department of Immunology, Faculty of Medicine, Immunogenetic Research Center, Mazandaran University of Medical Sciences, Sari, Iran F. i Talebpour Amir Ftaleb2001@yahoo.co.uk 7900319475328460015673 7900319475328460015673 No Department of Anatomy, Faculty of Medicine, Molecular and Cell Biology Research Center, Mazandaran University of Medical Sciences, Sari, Iran