en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: Radiation-induced lung injury is a common complication after esophageal, breast, etc. cancer radiotherapy. We aimed to evaluate the radioprotective effect of arbutin on acute radiation-induced lung damage in male rats. Materials and Methods: Fifty-two male Wistar rats were divided into 4 groups: (i) control group (n = 10), (ii) vehicle group (n = 10, received distilled water intraperitoneally (ip)), (iii) X-irradiation only (n=16, chest was irradiated to a single dose of 20 Gy x-rays) and (iv) arbutin + X-irradiation (n=16, 75 mg/kg of arbutin 2 hours before irradiation (ip), and then their chest was exposed to 20 Gy x-rays). For histopathological investigation, 8 animals of each group were sacrificed 8 weeks after treatment and the rest of them were sacrificed 3 months after treatment. Results: The histopathological analysis in 8 weeks after X-irradiation showed that there was a significant increase in inflammatory in X-irradiation only group compared to control group. The administration of arbutin 2 hours prior to X-irradiation significantly reduced inflammation and inflammatory factors such as macrophages, mast cell and neutrophil in arbutin + X-irradiation group compared to X-irradiation only group (P<0.05). The histopathologic investigation performed 3 months after lung irradiation indicated a significant reduction in fibrosis formation in arbutin + X-irradiation group compared to irradiation only group (P<0.05). Localized chest X-irradiation with 20 Gy caused histopathologic damage to the lungs for short -term. Conclusion: Arbutin has a great potential in reducing the histopathologic damage to lung tissue after thoracic irradiation.</div> Arbutin, lung irradiation, radioprotector, pneumonia, fibrosis. 413 420 http://ijrr.com/browse.php?a_code=A-10-1-859&slc_lang=en&sid=1 S.S.A. Jahanbani 7900319475328460017257 7900319475328460017257 No Department of Anatomical Sciences, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran A.H. Rezaeyan ahrezaeyan@gmail.com 7900319475328460017258 7900319475328460017258 No Department of Medical Physics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran H. Ghaffari 7900319475328460017259 7900319475328460017259 No Department of Medical Physics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran A.R. Babae 7900319475328460017260 7900319475328460017260 No Department of Anatomical Sciences, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran G.H. Haddadi 7900319475328460017261 7900319475328460017261 No Department of Radiology, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran M.M. Moeni 7900319475328460017262 7900319475328460017262 No Pathology and Stem Cell Research Center, Department of Pathology, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Ira A. Jomehzadeh 7900319475328460017263 7900319475328460017263 No Department of Medical Physics, Kerman University of Medical Sciences, Kerman, Iran S. Moatamedi 7900319475328460017264 7900319475328460017264 No Department of physiology and pharmacology, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran S.H. Eftekhar-Vaghefi sheftekharv@yahoo.com 7900319475328460017265 7900319475328460017265 Yes Department of Anatomical Sciences, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran