en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: The optimal radiation dose for oral cavity cancers treated with retrograde superselective intra-arterial chemoradiotherapy (SIACRT) is unclear. The aim of the present study was to evaluate the treatment outcome and toxicity in patients treated with <60 Gy compared with those treated with &ge;60 Gy to provide evidence for determining the optimal dose. Materials and Methods: Between January 2009 and December 2013, 159 oral cavity cancer patients were treated with SIACRT with curative intent at a single institution. One hundred and twenty-nine patients received &ge;60 Gy and 30 received <60 Gy. Local control (LC), disease-free survival (DFS), overall survival (OS), and toxicity were compared. Propensity score matching was performed to reduce bias. Results: The median follow-up period was 48 months (range, 2&ndash;88 months). LC (<60 Gy vs. &ge;60 Gy, 81.5% vs. 86.1% at 3 years, p = 0.534), DFS (68.8% vs. 72.4% at 3 years, p = 0.816), and OS (85.9% vs. 72.3% at 3 years, p = 0.132) were comparable between the two groups. There was also no difference in toxicity. However, the median overall treatment period was significantly shorter in the <60 Gy cohort (39 days vs. 49 days, p < 0.0001). Conclusion: The radiation dose may be reduced to <60 Gy when treating oral cavity cancers with SIACRT.</div> Catheterization, chemoradiotherapy, oral cancer, survival rate, toxicity. 531 538 http://ijrr.com/browse.php?a_code=A-10-1-860&slc_lang=en&sid=1 H. Kaizu hkaizu1980@ybb.ne.jp 7900319475328460016081 7900319475328460016081 Yes Department of Radiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan M. Hata 7900319475328460016082 7900319475328460016082 No Department of Radiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan K. Mitsudo 7900319475328460016083 7900319475328460016083 No Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan Y. Hayashi 7900319475328460016084 7900319475328460016084 No Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan E. Ito 7900319475328460016085 7900319475328460016085 No Department of Radiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan M. Sugiura 7900319475328460016086 7900319475328460016086 No Department of Radiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan S. Takano 7900319475328460016087 7900319475328460016087 No Department of Radiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan Y. Mukai 7900319475328460016088 7900319475328460016088 No Department of Radiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan I. Koike 7900319475328460016089 7900319475328460016089 No Department of Radiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan T. Koizumi 7900319475328460016090 7900319475328460016090 No Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan