en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: Adrenomedullin (AM) and its receptor, receptor activity-modifying protein (RAMP) 2 have pleiotropic regulatory functions in normal tissue and cancer tissue. AM is produced and secreted both numerous stromal cells and tumor cells. This study aims to investigate a possible role of AM and RAMP2 in the radiation exposure in the normal lung tissue. Materials and Methods: Four groups with 6 male adult Swiss Albino mice per group were investigated. The mice were subjected to a 500 cGy single-dose radiation exposure in the total body radiation device and lung tissues were collected. 1, 2, and 7 days after radiation exposure, with 1 reference group which was not exposed to radiation. Results: The general histology and the immunohistochemistry of the tissue samples prepared with anti- AM, anti&ndash;RAMP2, and monoclonal antibodies were investigated, yielding a statistically significant increase for AM on day 3 and for RAMP2 on day 1 after radiation exposure. Conclusion: The observed increase of AM and RAMP2 concentrations in the normal tissue matrix after radiation exposure may play a role in the side effects of radiotherapy.&nbsp;</div> AM, RAMP2, radiation, lung, carcinogens. 571 578 http://ijrr.com/browse.php?a_code=A-10-1-864&slc_lang=en&sid=1 M.K. Ozbilgin kemalozbilgin@yahoo.com 7900319475328460016141 7900319475328460016141 No Department of Histology and Embryology, Celal Bayar University School of Medicine, Manisa, Turkey G.Z. Karaman 7900319475328460016142 7900319475328460016142 No Department of Histology and Embryology, Celal Bayar University School of Medicine, Manisa, Turkey S. Gencur 7900319475328460016143 7900319475328460016143 No Department of Histology and Embryology, Celal Bayar University School of Medicine, Manisa, Turkey E. Gumustepe 7900319475328460016144 7900319475328460016144 No Department of Radiation Oncology, Ankara University School of Medicine, Ankara, Turkey C. Kurtman 7900319475328460016145 7900319475328460016145 No Department of Radiation Oncology, Ankara University School of Medicine, Ankara, Turkey