International Journal of Radiation Research
نشریه پرتو پژوه
Int J Radiat Res
Basic Sciences
http://ijrr.com
79
journal79
2322-3243
2345-4229
10.61186/ijrr
en
jalali
1400
7
1
gregorian
2021
10
1
19
4
online
1
fulltext
en
The risk of ischemic stroke in patients with head and neck cancer undergoing radiotherapy: a nationwide population-based ecological study
Radiation Biology
Radiation Biology
تحقيق بديع
Original Research
<div style="text-align: justify;">Background: The whole neck is often included in the radiation therapy (RT) field of head and neck cancer (HNC), and carotid vessels of the neck may be affected by radiation in a manner that increases the risk of ischemic stroke (IS). In the present study, we analyzed the relationship between RT for HNC and subsequent IS using a database managed by the Health Insurance Review & Assessment Service. Materials and Methods: A public insurance system was used to identify a nationwide cohort of patients diagnosed with HNC that underwent RT. The incidence of IS after RT was determined up to the end of December 2018, and associated risks were analyzed. In addition, patients that underwent frequent elective neck irradiation as determined by disease classification or less frequent elective neck irradiation were allocated to groups A and B, respectively. Results: 12,079 HNC patients that received RT between 2010 and 2014 were identified. 472 (3.9%) of the subjects experienced IS and incidence rates were > 5% for hypopharyngeal cancer and supraglottic cancer. The incidence of IS was 5.4% in patients > 60 years and 2.2% in patients < 60 years (relative risk (RR) 2.59). In addition, the incidence of IS was greater in group A than in group B (RR 1.29), and in men than in women (RR 1.33). Conclusion: When performing extensive RT involving the whole neck in older men, close follow-up and prophylactic medication should be considered to prevent IS.</div>
Radiotherapy, head and neck cancer, ischemic stroke
829
834
http://ijrr.com/browse.php?a_code=A-10-1-872&slc_lang=en&sid=1
H.J.
Han
7900319475328460019656
7900319475328460019656
No
Department of Neurosurgery and 2Department of Radiation Oncology, Dongguk University Gyeongju Hospital, Gyeongju, South Korea
H.
Jang
opencagejhs@gmail.com
7900319475328460019657
7900319475328460019657
Yes
Department of Radiation Oncology, Dongguk University Gyeongju Hospital, Gyeongju, South Korea