en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: To explore the efficacy of inducing chemotherapy in combination with the synchronized chemotherapy and radiotherapy on the local advanced cervical cancer. Materials and Methods: In this prospective cohort study, 212 patients with moderate or advanced cervical cancer who underwent their chemoradiotherapy were assessed. These patients were divided into the Group A, B and Group C. At 3 months, 1, 3, and 5 years after radiotherapy, efficacy and adverse effects evaluation were conducted. Data were analyzed using SPSS software. Results: Among Group A, B, and C, comparison over their short-term efficacy showed that the differences had no statistical significance (P > 0.05). The overall survival of patients in the Group A, B, and C was 90.12%, 85.29%, and 91.75% in the 1^st year, 85.19%, 79.41%, and 88.66% in the 3^rd year, and 82.72%, 73.53% and 84.54% in the 5^th year; differences among these OS showed no statistical significance (P > 0.05). While the dose modification factor (DMF) rate in Group C was higher than those in Group A and B (P < 0.05), showing its radioprotective effect. The incidence of the blood responses at Grade 3 or 4 in Group A was significantly lower than those in Group B and C (P < 0.05). Conclusion: Our results showed a radioprotective effect of inducing chemotherapy in combination with the synchronized chemotherapy and radiotherapy, while the possibility of risk of blood responses was relatively high. So further studies assessing blood reactions are recommended in the long term.</div> Cervical cancer, inducing chemotherapy, synchronized chemotherapy and radiotherapy, efficacy. 1001 1007 http://ijrr.com/browse.php?a_code=A-10-1-893&slc_lang=en&sid=1 Q. Xiong prof.qingnazhang@gmail.com 7900319475328460019796 7900319475328460019796 Yes Department of Gynecology, the Third Affiliated Hospital of Zhongshan University, Guangzhou, Guangdong510600, China. T. Zhang 7900319475328460019797 7900319475328460019797 No Department of Obstetrics and Gynecology, Guangzhou Women's and Children's Medical Center, Guangzhou, Guangdong510623, China S. Su 7900319475328460019798 7900319475328460019798 No Department of Gynecology, the Third Affiliated Hospital of Zhongshan University, Guangzhou, Guangdong510600, China.