en Radiobiology Radiobiology تحقيق بديع Original Research <div style="text-align: justify;">Background: The use of ¹³¹I in thyroid diseases is responsible for oxidative stress due to increased production of reactive oxygen species that may lead to multiple disorders in human. Purpose of this study was to mitigate the oxidative stress, generated by ¹³¹I therapy, by supplementation of phytoprotectants. Materials and Methods: After eliminating absconders, 97 volunteers of benign and malignant hyperthyroid diseases viz. control (n=42), standard (n=23), turmeric (n=19) and green cardamom (n=13) groups participated in this study. Vitamins were administered orally in standard group while turmeric (Curcuma&nbsp;longa) and green cardamom (Eletteria cardamomum) as phytoprotectants were given orally in the respective groups, 5 days before ¹³¹I therapy. The malondialdehyde (MDA) was measured in serum before (baseline), at 3-hours and after 2-weeks of ¹³¹I administration. Results: After radioactive iodine therapy (RAIT), there was a continuous decline of serum MDA in vitamin group (3.57 to 2.64 &micro;mol/L) in contrast to the control, where there was a ceaseless rise (3.01 to 3.69 &micro;mol/L) in the oxidative stress in terms of MDA. In akin to the standard group of vitamins, there was incessant decrease in both the treatment groups of green cardamom (3.55 to 2.89 &micro;mol/L) and turmeric (3.45 to 2.06 &micro;mol/L). The turmeric was proved as better phytoprotectant. Conclusion: The turmeric and green cardamom are good scavengers of free radicals and can be used as supplements along with ¹³¹I, in thyroid patients as radioprotective agents. The turmeric is more potent radioprotectant as compared to green cardamom.</div> &nbsp; Turmeric, green cardamom, radioprotectants, malondialdehyde, oxidative stress. 29 36 http://ijrr.com/browse.php?a_code=A-10-2188-57&slc_lang=en&sid=1 A. Rakha drarmalik45@gmail.com 7900319475328460020706 7900319475328460020706 Yes Department of Biochemistry, Punjab Medical College, Faisalabad, Pakistan Kh. Rehman 7900319475328460020707 7900319475328460020707 No Department of Biochemistry, University of Agriculture, Faisalabad, Pakistan M. Babar Imran 7900319475328460020708 7900319475328460020708 No Pakistan Institute of Nuclear Medicine, Faisalabad, Pakistan M. Shahid 7900319475328460020709 7900319475328460020709 No Department of Biochemistry, University of Agriculture, Faisalabad, Pakistan N. Jahan 7900319475328460020710 7900319475328460020710 No Department of Biochemistry, University of Agriculture, Faisalabad, Pakistan