en Radiobiology Radiobiology تحقيق بديع Original Research <div style="text-align: justify;">Background: To analyze the effectiveness and safety of combination of 3-dimensional conformal radiotherapy (3D-CRT) and S-LOX chemotherapy after the radical resection of localized progressive gastric cancer, so as to provide the reference for clinical treatment. Materials and Methods: We enrolled 82 localized progressive gastric cancer patients undergoing the radical resection of gastric cancer, and divided them using the random digit table into two groups: 39 in the chemotherapy group received the S-LOX chemotherapy after operation, and 43 in the combination group received the 3D-CRT in combination with S-LOX chemotherapy. After treatment, we evaluated the clinical efficacy, adverse reaction, survival rate and recurrence rate of patients in two groups. Results: After 6 cycles of treatment, we found no statistical significance in difference of the objective remission rate of patients in two groups (P > 0.05), while the patients in the combination group excelled in the clinical control rate (P < 0.05). In the combination group, 2-year survival rate and survival time of patients were all higher and longer than those in the chemotherapy group (all P < 0.05), with a lower recurrence rate (P < 0.05). Furthermore, comparison of the incidence of adverse reactions of patients between two groups showed no significant difference (P > 0.05). Conclusion: After the radical resection of the localized progressive gastric cancer,&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; 3D-CRT in combination with S-LOX chemotherapy improves the clinical control and survival of patients, while reduces the postoperative recurrence, but with no aggravation in side- or toxic-effect, thus worthy of being promoted in clinical practice.</div> &nbsp; Progressive gastric cancer, radical resection, chemotherapy, 3D-CRT, prognosis. 109 114 http://ijrr.com/browse.php?a_code=A-10-2188-69&slc_lang=en&sid=1 X. Yu 7900319475328460020802 7900319475328460020802 No Department of General Surgery II Ward, Linyi Central Hospital, Linyi, Shandong276400, China R. Zhang 7900319475328460020803 7900319475328460020803 No Department of Radiotherapy, Linyi Central Hospital, Linyi, Shandong276400, China S. Cao ZHANG.prof@yahoo.com 7900319475328460020804 7900319475328460020804 Yes Department of Radiotherapy Room, Linyi Central Hospital, Linyi, Shandong276400, China S. Cui 7900319475328460020805 7900319475328460020805 No Department of General Surgery II Ward, Linyi Central Hospital, Linyi, Shandong276400, China C. Liu 7900319475328460020806 7900319475328460020806 No Department of General Surgery II Ward, Linyi Central Hospital, Linyi, Shandong276400, China J. Wang 7900319475328460020807 7900319475328460020807 No Department of General Surgery II Ward, Linyi Central Hospital, Linyi, Shandong276400, China X. Cheng 7900319475328460020808 7900319475328460020808 No Department of General Surgery II Ward, Linyi Central Hospital, Linyi, Shandong276400, China