International Journal of Radiation Research
نشریه پرتو پژوه
Int J Radiat Res
Basic Sciences
http://ijrr.com
79
journal79
2322-3243
2345-4229
10.61186/ijrr
en
jalali
1400
10
1
gregorian
2022
1
1
20
1
online
1
fulltext
en
Therapeutic mechanism of 32-P application combined with timolol maleate for infantile superficial hemangioma
Radiobiology
Radiobiology
تحقيق بديع
Original Research
<div style="text-align: justify;">Background: This study aims to explore the therapeutic mechanism of <sup>32</sup>P application combined with timolol maleate for infantile superficial hemangioma. Materials and Methods: In this study, 60 nude mice were enrolled to establish the transplantation model of infantile hemangioma in nude mice. They were randomly divided into control group, administration group and combined administration group, with 20 mice in each group. The expressions of EGFL7 and VEGF were detected by RT-PCR, and the expressions of renin and ang II were detected by Western blot. Results: After the administration of timolol maleate, the expression of EGFL7, VEGF, renin and Ang II decreased (P < 0.05). The levels of EGFL7, VEGF, renin and Ang II were further down regulated by combined scheme of <sup>32</sup>P application and timolol maleate (P<0.05). Conclusion: <sup>32</sup>P application combined with timolol maleate can improve the therapeutic effect of infantile superficial hemangioma by inhibiting the expression of vascular endothelial growth factor, renin and angiotensin II.</div>
Hemangioma, timolol maleate, 32-P, angiotensin II, vascular endothelial growth factor.
157
162
http://ijrr.com/browse.php?a_code=A-10-2188-76&slc_lang=en&sid=1
R.X.
Ma
7900319475328460020857
7900319475328460020857
No
Department of Pharmacy, Xingtai People's Hospital, Xingtai, 054001, China
Z.L.
Li
13730133835@163.com
7900319475328460020858
7900319475328460020858
Yes
Department of Nuclear Medicine, Xingtai People's Hospital, Xingtai, 054001, China