International Journal of Radiation Research

en Clinical efficacy of peritoneal perfusion of bevacizumab in combination with venous chemotherapy of paclitaxel and Cis-platinum on the late-stage ovarian cancer and the effect on levels of VEGF, MIF, HE4 and CA125 Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: Often diagnosed at late stages, ovarian cancer is one of the leading causes of global cancer death. Major therapeutic choices include debugging surgery followed by chemotherapy and adjuvant therapy. Bevacizumab is an anti-VEGF medication used to treat various malignancies such as colorectal, lung, and renal cancer. The combination therapy of bevacizumab with other platinum-based medications has proved promising. Thus, researchers sought to evaluate the clinical efficacy of intraperitoneal bevacizumab combined with intravenous paclitaxel and cis-platinum and their subsequent effect on blood levels of VEGF, MIF, and CA125. Materials and Methods: Ninety patients diagnosed with late-stage ovarian cancer were enrolled. Patients were divided into control and experimental groups receiving intravenous and combination chemotherapy, respectively. Clinical efficacy and alterations in tumor markers blood levels were afterward compared between the two groups. Results: Combination therapy elicited significantly higher response and total effectiveness rates with a p-value of 0.015 and 0.002, respectively. Both treatments significantly decreased tumor markers blood levels (p-value<0.05), however, combination therapy significantly induced a more profound reduction (p-value<0.01). Conclusion: Intraperitoneal bevacizumab combination therapy with intravenous paclitaxel and cis-platinum is superior to intravenous chemotherapy alone in treating late-stage ovarian cancer and increases 1- and 2-year survival rates. </div> Ovarian cancer, Bevacizumab, chemotherapy, tumor markers. 335 340 http://ijrr.com/browse.php?a_code=A-10-1-912&slc_lang=en&sid=1 H. Chen 7900319475328460021563 7900319475328460021563 No Department of Gynecology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian,362000, China Q. Jiang 7900319475328460021564 7900319475328460021564 No Department of Oncology Radiotherapy, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, Jiangsu, 223002, China Y. Yin prof.yanruyin@hotmail.com 7900319475328460021565 7900319475328460021565 Yes Department of Gynecology, Traditional Chinese Medical Hospital of HuZhou, Zhejiang, 313000, China