en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">This study aimed to evaluate the relationship of tumor size and ultrasound (US) Breast Imaging Reporting and Data System (BI-RADS), and further analyze if tumor size can impact the evaluation for US features in patients with breast cancer. </span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Materials and Methods</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">In this retrospective study, preoperative US features and postoperative pathological results were collected from 498 patients with breast cancer. The association of BI-RADS classification with tumor size was analyzed, and the US features related to tumor size were determined. </span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Results</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">A</span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">significant association was found between tumor size and BI-RADS category, and tumor with small size was classified into the low BI-RADS category</span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US"> (</span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="font-style:italic"><span style="language:en-US">p </span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">< 0.05). Some US features including shape, growth orientation, microcalcification and color Doppler flow imaging (CDFI) were influenced by tumor size (</span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="font-style:italic"><span style="language:en-US">p</span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US"><0.001). </span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Conclusion</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US"> Tumor size can influence the diagnosis performance for US BI-RADS category in patients with breast cancer.</span></span></span></span></span></span></span></span></span></span></div> BI-RADS, breast cancer, CDFI, diagnosis, tumor size, ultrasonography. 341 346 http://ijrr.com/browse.php?a_code=A-10-1-913&slc_lang=en&sid=1 Q. Guo qiangguo3303@163.com 7900319475328460021567 7900319475328460021567 Yes Department of Ultrasound Medicine, Jinshan Branch of Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai, China Z. Dong 7900319475328460021568 7900319475328460021568 No Department of Laboratory Medicine, Jinshan Branch of Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai, China L. Jiang 7900319475328460021569 7900319475328460021569 No Department of Ultrasound in Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Institute of Ultrasound in Medicine, Shanghai, China L. Zhang 7900319475328460021570 7900319475328460021570 No Department of Ultrasound Medicine, the Second Affiliated Hospital of Harbin Medical University, Harbin, China Z. Li 7900319475328460021571 7900319475328460021571 No Department of Ultrasound Medicine, the Second Affiliated Hospital of Harbin Medical University, Harbin, China D. Wang 7900319475328460021572 7900319475328460021572 No Department of Ultrasound Medicine, the Second Affiliated Hospital of Harbin Medical University, Harbin, China