International Journal of Radiation Research

en Investigation of cardiac and pulmonary doses in patients with left sided breast cancer treated by radiotherapy with deep inspiration breath hold technique Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: Cardiac disease is a documented risk factor in left breast irradiation. In an attempt to reduce cardiac toxicity, different treatment techniques adapted to respiratory cycle phases have been developed. The aim of this study is to investigate the feasibility of the voluntary breath hold technique when irradiating the left breast in selected patients. Materials and Methods: The study included 20 patients with left sided breast cancer. For each patient, two computed tomography (CT) scans were acquired, one with the free breathing (FB) technique and one with the voluntary deep inspiration breath hold (DIBH) technique. Treatment plans were created using a field-in-field intensity-modulated radiation therapy technique. A dosimetric comparison was made between the two techniques for the heart, left anterior descending (LAD) coronary artery, ipsilateral lung and contralateral breast. Results: The average of the mean dose of the heart decreased from 7.7 Gy to 5.8 Gy and V20Gy (%) from 12.8% to 8.3% using the DIBH technique (p=0.009, p<0.001). The DIBH technique demonstrated significantly smaller maximum heart distance (2.0 cm vs. 0.9 cm, p < 0.001) and 8.0% reduction in LAD mean dose. Furthermore, Dmean for the ipsilateral lung was reduced from 12.8 Gy to 12.2 Gy and V20Gy (%) from 25.6% to 22.8%. Conclusions: In the treatment plans made using the DIBH technique, a significant reduction in the radiation dose delivered to the heart has been observed. In order to reduce long-term morbidity and mortality risks from cardiovascular disease affecting the survival of patients with left sided breast cancer, irradiation techniques such as the DIBH should be considered, especially for premenopausal patients.</div> left sided breast irradiation, deep inspiration breath hold, cardiac dose, radiotherapy. 369 375 http://ijrr.com/browse.php?a_code=A-10-1-918&slc_lang=en&sid=1 S. Parlar suleparlar@trakya.edu.tr 7900319475328460021603 7900319475328460021603 Yes Trakya University, Vocational School of Health, Radiotherapy Department, Edirne/Turkey, G. Var 7900319475328460021604 7900319475328460021604 No Ministry of Health Ankara City Hospital, Department of Radiation Oncology, Ankara/Turkey R. Cosar 7900319475328460021605 7900319475328460021605 No Trakya University Faculty of Medicine, Department of Radiation Oncology, Edirne/Turkey M. Dogan 7900319475328460021606 7900319475328460021606 No Trakya University Faculty of Medicine, Department of Radiation Oncology, Edirne/Turkey Y. Ozguven 7900319475328460021607 7900319475328460021607 No Trakya University, Vocational School of Health, Radiotherapy Department, Edirne/Turkey, D. Nurlu 7900319475328460021608 7900319475328460021608 No Trakya University Faculty of Medicine, Department of Radiation Oncology, Edirne/Turkey M. CemUzal 7900319475328460021609 7900319475328460021609 No Trakya University Faculty of Medicine, Department of Radiation Oncology, Edirne/Turkey