en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:inter-word"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">We compare plans involving two different stereotactic radiotherapy devices: Cyberknife (CK) and Helical Tomotherapy (HTT) and their results on the lumbarvertebra targets.&nbsp;</span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Materials and Methods</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span>&nbsp;<span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">Ten simulation tomographs of the first lumbar vertebra were selected from among the tomographies of patients who had previously undergone SBRT for any reason. In each planning tomography, two separate clinical target volumes (CTV) were drawn at the first lumbar vertebra, we used 2%, 95% and 98% doses of the target volume (D2, D95, D98) in the plan evaluation. The 2% dose of the planning target volume (PTV) was used for comparison with the hot spot; the 95% dose coverage of CTV was used for the target coverage comparison, and the 98% dose of the target volume was used for the dose volume histogram &quot;shoulder&quot; metric definitionTheHomogeneity Index (HI), new Conformity Index (nCI) and Gradient Index (GI) were evaluated for each planning system and target.&nbsp;</span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Results</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span>&nbsp;<span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">In both groups, CTV1 and CTV2, when compared with D95, the coverage for HTT was found statistically significantly higher. D98 was found to be statistically significantly higher with HTT. In both targets, the CKplans were found to have a higher hot area (D2), and inhomogeneous plans were obtained when compared to HTT. The NCI results were similar, and GI was higher with HTT.&nbsp;</span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Conclusion</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">In lumbar vertebra stereotactic radiotherapy, more inhomogeneous plans were obtained with Cyberknife than with the Helical Tomotherapy device. A better gradient index was achieved with Cyberknife, while better coverage was achieved on the HTT plan.</span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Tahoma"><span style="font-style:italic"><span style="language:en-US"></span></span></span></span></span></span></span></span></span></div> <span style="font-size:10pt"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black">&nbsp;</span></span></span></span><br> &nbsp; Vertebra metastasis, stereotactic body radiotherapy (SBRT), cyberknife, helical tomotherapy (HTT). 531 535 http://ijrr.com/browse.php?a_code=A-10-1-941&slc_lang=en&sid=1 N. Isık nacisik@hotmail.com 7900319475328460021892 7900319475328460021892 Yes Lutfi Kirdar Kartal Egitim ve Arastirma Hastanesi, Radyasyon Onkolojisi Klinigi, Istanbul, Turkey E. Algül 7900319475328460021893 7900319475328460021893 No Lutfi Kirdar Kartal Egitim ve Arastirma Hastanesi, Radyasyon Onkolojisi Klinigi, Istanbul, Turkey G. Yaprak 7900319475328460021894 7900319475328460021894 No Lutfi Kirdar Kartal Egitim ve Arastirma Hastanesi, Radyasyon Onkolojisi Klinigi, Istanbul, Turkey A. Özen 7900319475328460021895 7900319475328460021895 No Lutfi Kirdar Kartal Egitim ve Arastirma Hastanesi, Radyasyon Onkolojisi Klinigi, Istanbul, Turkey