International Journal of Radiation Research

en Extreme hypofractıonated radiosurgery in recurrent inoperable High-Grade Ultra-Large gliomas Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: To elucidate the efficacy and toxicity of brain re-radiotherapy for recurrent large inoperable gliomas using radiosurgery. Materials and Methods: Between 2014 and 2018, extreme hypofractionated radiosurgery was performed using Accuray’s Cyberknife® system on 14 lesions (12 patients)  grade 4 recurrence lesions of 6 patients with anaplastic astrocytoma and 6 patients with glioblastoma who had previously undergone surgery and cranial radiotherapy and had a local-regional recurrence. Six patients (8 lesions) were given a biologic effective dose (BED10) of 48 Gy and lower, and six patients were given a BED10 of 59.5 Gy and higher. The Response Assessment in Neuro-Oncology Criteria (RANO) were used for tumor response, and the Common Terminology for Adverse Events (CTCAE) was used for adverse effect assessment. The primary endpoint was determined as overall survival, and first treatment and salvage treatment time. Results: The median age of the patients was 43 years, and the median Karnofsky Performance Status (KPS) was 70. The median time from the first radiotherapy to death was 34 months. The median time from the previous radiotherapy was 29.5 months (R:17-40). The median survival was 10 months for those with recurrence before 29.5 months and 11 months for those with recurrence after 29.5 months. The median total tumor volume was 29.224 mL (~30 mL). One grade 4 toxicity was observed. Conclusion: Radiosurgery can be used effectively as salvage therapy in ultra-large inoperable gliomas.</div> Re-irradiation, radiosurgery, high-grade glioma, salvage, hypofractionated, recurrent. 643 648 http://ijrr.com/browse.php?a_code=A-10-1-957&slc_lang=en&sid=1 T. Berber tanjuberber@hotmail.com 7900319475328460022106 7900319475328460022106 Yes Okmeydani Training and Research Hospital, Radiation Oncology Department, Istanbul, Turkey I. Harmankaya 7900319475328460022107 7900319475328460022107 No Okmeydani Training and Research Hospital, Radiation Oncology Department, Istanbul, Turkey F. Aksaray 7900319475328460022108 7900319475328460022108 No Okmeydani Training and Research Hospital, Radiation Oncology Department, Istanbul, Turkey Y. Büyükpolat 7900319475328460022109 7900319475328460022109 No Okmeydani Training and Research Hospital, Radiation Oncology Department, Istanbul, Turkey F. Adatepe 7900319475328460022110 7900319475328460022110 No Okmeydani Training and Research Hospital, Radiation Oncology Department, Istanbul, Turkey B.D. Yilmaz 7900319475328460022111 7900319475328460022111 No Okmeydani Training and Research Hospital, Radiation Oncology Department, Istanbul, Turkey S.T. Dinçer 7900319475328460022112 7900319475328460022112 No Okmeydani Training and Research Hospital, Radiation Oncology Department, Istanbul, Turkey G. Coşgun 7900319475328460022113 7900319475328460022113 No Okmeydani Training and Research Hospital, Radiation Oncology Department, Istanbul, Turkey Ç. Numanoglu 7900319475328460022114 7900319475328460022114 No Okmeydani Training and Research Hospital, Radiation Oncology Department, Istanbul, Turkey M.N. Güven 7900319475328460022115 7900319475328460022115 No Okmeydani Training and Research Hospital, Radiation Oncology Department, Istanbul, Turkey M.E. Gül 7900319475328460022116 7900319475328460022116 No Okmeydani Training and Research Hospital, Radiation Oncology Department, Istanbul, Turkey C. Yildirim 7900319475328460022117 7900319475328460022117 No Istanbul University Faculty of Medicine, Radiation Oncology Department, Istanbul, Turkey A.A. Erken 7900319475328460022118 7900319475328460022118 No Okmeydani Training and Research Hospital, Radiation Oncology Department, Istanbul, Turkey