en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">Breast cancer (BC) is a global threat to women&rsquo;s health. Volumetric intensity modulated arc therapy (VMAT) is effective for the local control of BC. This study evaluated the pulmonary and cardiac radiotherapeutic dosage to provide information for estimating normal tissue complication probability (NTCP) once malignant tumors appear in patients&rsquo; left and right breasts. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Materials and Methods</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">We conducted a retrospective analysis of VMAT regimen of 40 patients with BC, among whom 20 patients (group 1) were diagnosed with right BC and 20 patients (group 2) with left BC. The pulmonary and cardiac dose volume histogram (DVH) parameters were acquired and compared between patients with left and right BC treated with VMAT. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Results</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">Generally, the pulmonary and cardiac dosages in patients with right BC were larger than in those with left BC. For the lung, the V</span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="language:en-US">₂₀</span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US"> and V</span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="language:en-US">₅</span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US"> of right BC patients were significantly higher, relative to the left BC patients (P<0.05). For the heart, the V</span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="language:en-US">₅</span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US"> and V</span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="language:en-US">₁₀</span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US"> of right BC patients were significantly lower, compared to left BC patients, with differences of up to 20% and 10%, respectively (both P<0.05). V</span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="language:en-US">₂₀</span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">, V</span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="language:en-US">₃₀</span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">, and V</span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="language:en-US">₄₀</span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US"> as low as zero were observed for right BC patients. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Conclusions</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">When treating left BC, image guidance and respiratory management techniques should be applied to limit radiotherapy complications that occur in the heart because of patient positioning and respiratory movement.</span></span></span></span></span></span></span></span></span></div> <span style="font-size:10pt"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black">&nbsp;</span></span></span></span><br> &nbsp; Left breast cancer, right breast cancer, VMAT, heart dose, lung dose. 761 765 http://ijrr.com/browse.php?a_code=A-10-1-975&slc_lang=en&sid=1 H. Zhang yinhongtao1982@outlook.com 7900319475328460022547 7900319475328460022547 No Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China H. Yin wenchengshao@outlook.com 7900319475328460022548 7900319475328460022548 No Department of Radiation Oncology, Harbin Medical University Cancer Hospital, Harbin, China W. Shao 7900319475328460022549 7900319475328460022549 No Department of Radiation Physics, Harbin Medical University Cancer Hospital, Harbin, China