International Journal of Radiation Research

en The application of automated volume scanner in bone age assessment Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: Radiograph of hand and wrist has been widely used in children's bone age assessment (BAA). However, ionizing radiation may be harmful for children in the future. Therefore, alternative methods have been attempted for the evaluation of children's bone age. Here, we reported an automated volume scanner (AVS) in assessing the biological age of children in comparison with X-ray radiograph as the gold standard. Material and Methods: Total 22 children (13 male and 9 female) with short stature or precocious puberty were enrolled into this study. Their chronological age ranged from 4 to 14 years old. The children's left hand-wrist was scanned with the AVS by putting them into a water sink containing tape water. Coronal images of the left hand-wrist were reconstructed and compared with X-ray images. Results: The number of patients whose hand-wrist bones (except for the first metacarpal sesamoid bone and the secondary ossification center of the first metacarpal bone) identified by AVS image was not significantly different from that by X-ray image. In addition, the total number of observed bones in each patient were not significantly different between the two methods. The concordance rate (percentage of patients whose hand-wrist bone presented in both AVS image and X-ray image) was high and the inter-observer variance of BA was small. Conclusions: The AVS method was highly correlated with the standard radiograph for children's bone age assessment with small inter-observer variability. This novel AVS method could be an alternative method in clinical practice for bone age assessment with higher safety and reliability.</div> radioactive automated volume scanner, bone age assessment, chronological age. 767 772 http://ijrr.com/browse.php?a_code=A-10-1-976&slc_lang=en&sid=1 J. Shi 7900319475328460022551 7900319475328460022551 No Department of Imaging Diagnosis Center, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P.R. China Y. Chen 7900319475328460022552 7900319475328460022552 No Department of Endocrinology and Genetic Diseases, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China L. Yang 7900319475328460022553 7900319475328460022553 No Department of Imaging Diagnosis Center, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P.R. China Z. Ni 7900319475328460022554 7900319475328460022554 No Ultrasound Department, Siemens Healthineers Ltd. China J. Du duizhi0360603636@163.com 7900319475328460022555 7900319475328460022555 Yes Department of Imaging Diagnosis Center, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P.R. China Q. Wang wfv313@163.com 7900319475328460022556 7900319475328460022556 No Department of Imaging Diagnosis Center, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P.R. China