International Journal of Radiation Research

en Modulatory effects of Zn oxide nanoparticles on cardiotoxicity and hematological changes in irradiated rats Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: Cardiotoxicity is one of the most serious complications of radiation. Nanoparticles, has gained increasing attention as therapeutic agents. This work aims to evaluate the beneficial effect of zinc oxide nanoparticles (ZnONPs) on the cardiotoxicity induced by ionizing radiation. Materials and Methods: Twenty eight male rats were included in the study. Animals were categorized into four groups (n=7),  group I: (control), group II: rats were irradiated with a single dose of ɤ radiation (6Gy), group III: rats injected with ZnONPs (10mg /Kg b.wt), intrapritoneally for two weeks (5days/week), group IV (treated):  irradiated rats received ZnONPs intrapritoneally with the same dose for two weeks after 24hr of irradiation. Results: γ-irradiation caused a significant elevation in the levels of creatine phosphokinase, creatine kinase, lactate dehydrogenase, troponin I, fibrinogen and C-reactive protein. Additionally, a noticeable increase in the lipid content including cholesterol, triglycerides and low density lipoprotein with concomitant decline in high density lipoprotein and finally, a marked decrease in hematological parameters as compared to the control group. These changes manifested good amelioration in the groups injected with ZnONPs. Conclusion: Based on these findings, it can be argued that treatment with ZnONPs reduces the extent of radiation damage by providing significant hypolipidemic, anti-inflammatory and antioxidant effects in irradiated rats.</div> Gamma irradiation, Zn oxide nanoparticles, cardiotoxicity. 851 855 http://ijrr.com/browse.php?a_code=A-10-1-988&slc_lang=en&sid=1 M.M. Abbas dr.manammounir2021@yahoo.com 7900319475328460022711 7900319475328460022711 Yes Biological Applications Department, Isotopes Applications Division, Nuclear Research Center, Egyptian Atomic Energy Authority, Cairo, Egypt A.H. Mahmoud 7900319475328460022712 7900319475328460022712 No Biological Applications Department, Isotopes Applications Division, Nuclear Research Center, Egyptian Atomic Energy Authority, Cairo, Egypt H.A. Abdelmonem 7900319475328460022713 7900319475328460022713 No Biological Applications Department, Isotopes Applications Division, Nuclear Research Center, Egyptian Atomic Energy Authority, Cairo, Egypt