en Radiation Biology Radiation Biology مطالعه موردي Case Report <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-family:Calibri"><span style="language:en-US">Recent advances in surgical techniques, chemotherapy and radiotherapy led to significant increase in the number of long-term cancer survivors, but on other hand with increased probability of adverse effects, including the development of a secondary malignant neoplasm. This is especially important to consider when there is the need to provide treatment recommendations for patients undergoing radiotherapy keeping in mind the potential risks of toxicity associated with possession of specific genetic variants</span></span><span lang="en-US" style="font-family:Calibri"><span style="language:en-US">.</span></span><span lang="en-US" style="font-family:Calibri"><span style="language:en-US"> We reported the clinical case of a patient in whom rare malignancies associated to genetic mutation have been treated and managed in the best way thanks to the support of radiotherapist. In particular a male patient with positive family history of BRCA2 mutation, developed breast cancer after radiotherapy for a rare tonsillar non-Hodgkin Lymphoma. We highlight that the knowledge of all aspects of the diseases, of all treatments secondary effects, in particular of ionizing radiation in patients with potential genetic risk of toxicity, allowed an optimal management of the case.</span></span></span></span></span></span></span></span></div> Male breast cancer, BRCA2 mutation, secondary malignant neoplasm, non-Hodgkin lymphoma, radiation therapy. 163 167 http://ijrr.com/browse.php?a_code=A-10-1-1021&slc_lang=en&sid=1 F. Tramacere 7900319475328460023194 7900319475328460023194 No Section of radiotherapy, A. Perrino Hospital, 72100 Brindisi, Italy A.R. Pisani 7900319475328460023195 7900319475328460023195 No Section of Nuclear Medicine, DIM, University “Aldo Moro”, 70124 Bari, Italy E. Maggiulli 7900319475328460023196 7900319475328460023196 No Medical Physics, ASL Brindisi, 72100 Brindisi, Italy M. Moschetta 7900319475328460023197 7900319475328460023197 No Division of Diagnostic Imaging, Department of Emergency and Organ Transplantation (DETO), Aldo Moro University, Medical School, Bari, Italy A. Sardaro angelasardaro@libero.it 7900319475328460023198 7900319475328460023198 Yes Section of radiotherapy, DIM, University “Aldo Moro”, 70124 Bari, Italy C. Altini 7900319475328460023199 7900319475328460023199 No Section of Nuclear Medicine, DIM, University “Aldo Moro”, 70124 Bari, Italy A. Sciacqua 7900319475328460023200 7900319475328460023200 No Section of Nuclear Medicine, DIM, University “Aldo Moro”, 70124 Bari, Italy M. Portaluri 7900319475328460023201 7900319475328460023201 No Section of radiotherapy, A. Perrino Hospital, 72100 Brindisi, Italy