en Radiation Biology Radiation Biology گزارش کوتاه Short Report <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">Mamuju is regarded as a high background radiation location (HBRA). The local population&#39;s cells may be harmed by the high ionizing radiation dosage in this region. Micronuclei (MN), nucleoplasmic bridges (NPB), nuclear buds (NBUD), and 8-shaped blood cells can be used to detect cytogenetic abnormalities. By comparing blood samples from HBRA to control site samples, this study focused on determining the impacts of high-risk levels of natural radiation in the cells. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Material and Methods</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US"> The study employed a cytokinesis-block micronucleus cytome (CBMN Cyt) test. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Results</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">In comparison to the control group, the study group had a higher nuclear division index (NDI) and a higher frequency of all abnormalities. The formation of MN and 8-shaped nuclei was significantly influenced by high natural radiation, whereas levels of NPB and NBUD were not significantly affected. Cytogenetic abnormalities were within normal limits and did not correlate with age or gender. </span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Conclusion</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">: </span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="language:en-US">Chronic high background radiation exposure impacted human lymphocyte cell growth and the levels of certain biomarkers.</span></span></span></span></span></span></span></span></span></div> CBMN cyt assay, cytogenetic abnormalities, high background radiation area, Mamuju residents 601 604 http://ijrr.com/browse.php?a_code=A-10-1-1085&slc_lang=en&sid=1 N. Khoirunnisa 7900319475328460024464 7900319475328460024464 No Faculty of Science and Technology, Islamic State University of Syarif Hidayatullah, Jakarta, Indonesia S. Purnami 7900319475328460024465 7900319475328460024465 No Research Center for Safety, Metrology, and Nuclear Quality Technology, Research Organization for Nuclear Energy (ORTN), National Research and Innovation Agency (BRIN), Jakarta, Indonesia D. Tetriana 7900319475328460024466 7900319475328460024466 No Research Center for Safety, Metrology, and Nuclear Quality Technology, Research Organization for Nuclear Energy (ORTN), National Research and Innovation Agency (BRIN), Jakarta, Indonesia D. Dasumiati 7900319475328460024467 7900319475328460024467 No Faculty of Science and Technology, Islamic State University of Syarif Hidayatullah, Jakarta, Indonesia D. Ramadhani 7900319475328460024468 7900319475328460024468 No Research Center for Radioisotopes, Radiopharmaceuticals and Biodosimetry Technology, Research Organization for Nuclear Energy (ORTN), National Research and Innovation Agency (BRIN), Tangerang Selatan, Banten, Indonesia H.N.E. Surniyantoro harr005@brin.go.id 7900319475328460024469 7900319475328460024469 Yes Research Center for Radioisotopes, Radiopharmaceuticals and Biodosimetry Technology, Research Organization for Nuclear Energy (ORTN), National Research and Innovation Agency (BRIN), Tangerang Selatan, Banten, Indonesia M. Syaifudin 7900319475328460024470 7900319475328460024470 No Research Center for Radioisotopes, Radiopharmaceuticals and Biodosimetry Technology, Research Organization for Nuclear Energy (ORTN), National Research and Innovation Agency (BRIN), Tangerang Selatan, Banten, Indonesia