en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">To explore computerized tomography (CT) imaging features of pulmonary fungal infection (PFI) in patients with acute leukemia (AL) after chemotherapy. </span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Materials and Methods</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">: </span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">Totally 116 AL patients who received chemotherapy in our hospital from June 2016 to April 2023 participated into this study, and the pulmonary fungal infection was confirmed by laboratory examination and clinical antifungal treatment. The CT image signs, lesion distribution, CT concomitant signs and main types of fungal infection were analyzed. </span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Results</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">CT image signs of two main types, nodule/mass type and mixed type were recorded, with76 cases of nodular/mass type and 40 cases of mixed type. There were 372 lesions in nodules/mass cases, mainly in the upper lung (46.24%). In these 372 lesions, 113 micro-tubercle, 138 small nodules, 115 nodules and 6 masses were included. There were 88 cases of halo sign, 26 cases of cavity, and 25 cases of air crescent sign. Candida albicans was the most common pathogenic fungal strain, followed by aspergillus, candida tropicalis, candida glabrata, candida parapsilosis, cryptococcus, candida dubliniensis, mucor, candida krusei and candida rugosa. </span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Conclusion</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">The CT manifestations of AL complicated with pulmonary fungal infection after chemotherapy were various, most of which had no characteristics, but the &ldquo;halo sign&rdquo; and &ldquo;air crescent sign&rdquo; had certain specificity. The combined CT and clinical manifestations can narrow the range of differential diagnosis. When the diagnosis still cannot be confirmed, diagnostic therapy or early diagnosis by fungal culture and histological examination can be performed.</span></span></span></span></span></span></span></span></span></span></div> Pulmonary fungal infection, acute leukemia, chemotherapy, computerized tomography. 621 625 http://ijrr.com/browse.php?a_code=A-10-1-1090&slc_lang=en&sid=1 D. Kong 7900319475328460024825 7900319475328460024825 No Department of Imaging, The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu 223300, China J. Guo 7900319475328460024826 7900319475328460024826 No Department of Hematology, People's Hospital of RiZhao, Rizhao, Shandong 276800, China Q. Li 7900319475328460024827 7900319475328460024827 No Department of Medical Laboratory, The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu 223300, China J. Liu 7900319475328460024828 7900319475328460024828 No Department of Imaging, The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu 223300, China L. Song songlixiao510@126.com 7900319475328460024829 7900319475328460024829 Yes Department of Hematology, The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu 223300, China