en Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:newspaper"><span style="text-kashida-space:50%"><span style="line-height:119%"><span style="font-family:Calibri"><span style="color:black"><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Background</span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-weight:bold"><span style="language:en-US">:</span></span></span></span></span> <span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">To determine the therapeutic effect of ultrasound-guided epidermal growth factor (EGF) injection combined with carbon dioxide laser on facial acne scars. </span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Materials and Methods: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">One hundred patients with facial acne scars admitted to the dermatology department from October 2021 to October 2022 were selected as the subjects of this study. The observation group (OG) received ultrasound guided EGF injection combined with carbon dioxide 2 (CO</span></span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">₂</span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">) laser treatment, and the control group (CG) received CO</span></span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">₂</span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US"> laser treatment alone. The clinical outcomes and the recovery time after treatment were recorded for both groups of patients. Quantitative skin analysis including skin spots, red mass, pores and wrinkles were performed before and after treatment by VISIA skin detector, and inflammatory factors levels were measured. </span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Results: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">The pain duration, erythema duration, incrustation time, decrustation time and incidence of adverse reactions in the OG were lower than those in the CG, while the total efficiency of treatment was higher than that in the CG (P<0.05). In addition, the results of quantitative analysis of skin spots, red matter, pores and wrinkles were higher in the OG and inflammatory factors levels were lower in the CG after treatment (P<0.05). </span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:#1f497d"><span style="font-style:italic"><span style="font-weight:bold"><span style="language:en-US">Conclusion: </span></span></span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">EGF combined with CO</span></span></span></span><span lang="en-US" style="font-size:5.9939pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US">₂</span></span></span></span><span lang="en-US" style="font-size:9.0pt"><span style="font-family:Calibri"><span style="color:black"><span style="language:en-US"> laser can effectively improve scarring symptoms and shorten the recovery period in patients with facial acne scars.</span></span></span></span></span></span></span></span></span></span></div> Epidermal growth factor, ultrasonography, CO2 lasers, cicatrix, acne vulgaris. 713 717 http://ijrr.com/browse.php?a_code=A-10-1-1111&slc_lang=en&sid=1 L. Liao 7900319475328460025082 7900319475328460025082 No Department of Medical Cosmetology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu, 215008, China F. Lu fengxialu@126.com 7900319475328460025083 7900319475328460025083 Yes Department of Ultrasound, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu, 215008, China