International Journal of Radiation Research

en Hepatoprotective effects of the mixed decoction of Inula cappa and Serissa japonica in acute liver injury mouse model Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: To explore the effectiveness of the mixed decoction of Inula cappa and Serissa japonica (IS) on acute liver injury model. Materials and Methods: Sixty carbon tetrachloride (CCl4)-induced mice models were divided into bifendate group (0.2 g/kg) and IS (2, 1and 0.5 g/kg) groups, model group, and control group randomly. Liver function biomarkers aspartate aminotransferase (AST), alanine amiotransferase (ALT), and oxidative stress biomarkers superoxide dismutase (SOD), malonic dialdehyde (MDA) were measured in each group. Hematoxylin and eosin (HE) staining was used to detect the liver tissues. Results: The necrosis degree and scope, and the structural damage of hepatocyte were significantly ameliorated in the bifendate, IS (2 g/kg) and IS (1 g/kg), compare to model group. IS and bifendate could significantly inhibit the liver index, reduce liver function biomarkers levels and the content of MDA in the liver of acute liver injury mice, and improve the activity of SOD. The serum level of AST was 147.162 (Control), 736.023 (Model), 370.285 (Bifendate), 325.589 (High-dose IS), 407.205 (Middle-dose IS), and 438.631 U/L (Low-dose IS) while the level of ALT was 44.804 (Control), 474.825 (Model), 156.812 (Bifendate), 157.02 (High-dose IS), 217.399 (Middle-dose IS), and 255.649 U/L (Low-dose IS). The content of MDA increased in model and treatment groups compared to control, while the activity of SOD was 69.362 (Control), 53.208 (Model), 64.77 (Bifendate), 73.389 (High-dose IS), 65.173 (Middle-dose IS), and 61.755 (Low-dose IS). Compared to the model group, high-dose IS group exerted significant hepatoprotective effect (p<0.05). Conclusion: The mixed decoction of Inula cappa and Serissa japonica was able to protect acute liver injury.</div> Inula cappa, Serissa japonica, mixed decoction, CCl4, acute liver injury. 765 768 http://ijrr.com/browse.php?a_code=A-10-1-1115&slc_lang=en&sid=1 X.H. Qiu 7900319475328460025126 7900319475328460025126 No Physiological Science Laboratory, Guangdong Medical University, Dongguan, 523000, Guangdong, China Y. Jiang 7900319475328460025127 7900319475328460025127 No Physiological Science Laboratory, Guangdong Medical University, Dongguan, 523000, Guangdong, China B. Chen 7900319475328460025128 7900319475328460025128 No Physiological Science Laboratory, Guangdong Medical University, Dongguan, 523000, Guangdong, China P. Zhong 7900319475328460025129 7900319475328460025129 No Physiological Science Laboratory, Guangdong Medical University, Dongguan, 523000, Guangdong, China X. Liu xialiu4043@163.com 7900319475328460025130 7900319475328460025130 Yes Physiological Science Laboratory, Guangdong Medical University, Dongguan, 523000, Guangdong, China