International Journal of Radiation Research

en CO2 laser surgery for laryngeal cancer: A meta-analysis and systematic review Radiation Biology Radiation Biology مقاله مروری Review article <div style="text-align: justify;">Background: To evaluate the effectiveness and safety of CO2 laser surgery (CO2-LS) in treating patients with laryngeal cancer (LC) by comparing it with other therapeutic modalities. Materials and Methods: The randomized controlled trials of CO2-LS for LC from the creating day of databases to February 2023 were searched on PubMed, Embase, Web of science databases and the Cochrane library, without language restrictions. Data were extracted independently by two investigators, followed by the article quality assessment and cross-check. This meta-analysis involved five studies with good quality, covering 405 LC patients. Results: Data analysis demonstrated a higher voice handicap index (VHI) in CO2-LS-treated patients compared to the control group at 6 months postoperatively [Odds Ratio (OR) = 1.12, 95% confidence intervals (CI) (0.19, 2.04), P = 0.02], but a lower shimmer value at 3 months postoperatively [OR = 1.04, 95% CI (0.92, 1.17), P<0.00001]. The control group exhibited a lower postoperative mucosal stability compared to the CO2-LS group [OR = 0.41, 95%CI (0.21, 0.79), P=0.008]. The subgroup analysis showed more operation time [OR = 3.48, 95% CI (2.86, 4.10), P<0.00001] compared to the CO2-LS group, with statistically significant difference. Conclusions: Comparing to other treatment modalities, CO2-LS is advantageous in mucosal recovery in LC patients, but not in postoperative survival and vocal quality.</div> Carbon dioxide laser surgery, laryngeal cancer, effectiveness, safety, meta-analysis. 1 7 http://ijrr.com/browse.php?a_code=A-10-1-1130&slc_lang=en&sid=1 S. Zheng zhengsy2048@163.com 7900319475328460026134 7900319475328460026134 Yes Department of Otorhinolaryngology, General Hospital of Fushun Mining Bureau of Liaoning Health Industry Group, FuShun City, Liaoning Province, China Y. Zhan 7900319475328460026135 7900319475328460026135 No Department of Otorhinolaryngology, Air Force Hospital of the Northern Theatre of the People's Liberation Army, ShenYang City, Liaoning Province, China F. Bao 7900319475328460026136 7900319475328460026136 No Department of Pharmacy, Fushun Hospital of Traditional Chinese Medicine, FuShun City, Liaoning Province, China M. Su 7900319475328460026137 7900319475328460026137 No Department of Operating room, Shengjing Hospital Affiliated to China Medical University, ShenYang City, Liaoning Province, China T. Gong 7900319475328460026138 7900319475328460026138 No Department of Second Interventional Medicine, Shengjing Hospital Affiliated to China Medical University, ShenYang City, Liaoning Province, China