International Journal of Radiation Research

en Protective effect of irradiated-Ficus carica dried leaf against hepatic-damage induced by ethanol in male rats Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: This study aimed to evaluate the effects of gamma rays and electron beams (5kGy) on the chemical content of dried fig leaves. In addition, the hepatoprotective effect of irradiated-dried fig leaves powder (GFLP) against ethanol (EtOH)-induced hepatotoxicity in rats was investigated. Materials and Methods: The 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, sugar, total phenolic, total flavonoid content, phytate, and tannin contents of either raw or irradiated dried fig leaves were detected in this study. For the experimental study, 28 male rats were divided into four groups; Group C, control; Group 2: received an oral dose of ethanol (0.5 ml/100 gm b.wt. /day /5 weeks) and Groups 3-4: rats fed daily (60 min after EtOH injection) on either raw or irradiated fig leaves powder (4% of the weight of the diet). Results: It was observed from the results that gamma-irradiation (5 kGy) resulted in a higher increase in DPPH radical scavenging activity, sugar, total phenolic and total flavonoid content, and a higher reduction in phytate and tannin contents than e-beam irradiation. The results of the experimental study revealed that treatment of EtOH-rats with GFLP resulted in a significant reduction in the serum blood alcohol level, the activity of some liver enzymes, level of tumor necrotic factor-alpha, interleukin-6, malondialdehyde, and lipid profile contents associated with significant elevation in the level of high-density lipoprotein-cholesterol, hepatic total antioxidant capacity and glutathione content relative to EtOH-group. Conclusion: The enhanced antioxidant activities of Ficus carica leaves through irradiation could be applied as a natural antioxidant source in foodstuff.</div> Ficus carica, gamma irradiation, e-beam, ethanol. 77 83 http://ijrr.com/browse.php?a_code=A-10-1-1140&slc_lang=en&sid=1 A.A. Mansour 7900319475328460025886 7900319475328460025886 No Food Irradiation Research Department, Natural Products Department, National Centre for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt A.M. Abdul Azeem alyncrt @yahoo.com 7900319475328460025887 7900319475328460025887 Yes Food Irradiation Research Department, Natural Products Department, National Centre for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt A.N. El shahat 7900319475328460025888 7900319475328460025888 No Food Irradiation Research Department, Natural Products Department, National Centre for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt M.H.M. Abd el Megid 7900319475328460025889 7900319475328460025889 No Natural Products Department, National Centre for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt