International Journal of Radiation Research

en Protective efficacy of luteolin against γ-rays induced early pneumonitis in rats Radiation Biology Radiation Biology تحقيق بديع Original Research <div style="text-align: justify;">Background: Radiotherapy treats over 70% of thoracic tumours; however, the technique frequently causes radiation-pneumonitis. Luteolin exhibits anti-inflammatory properties and inhibits chemotaxis release. The radio protective effects of luteolin on γ-rays-induced pneumonitis in rats were evaluated. Materials and Methods: Thirty-two rats were distributed into four groups. Rats were exposed to 8.5Gy-γ-rays then, treated with or without luteolin for 20-days. Oxidative-stress, antioxidant, anti-inflammatory markers levels, collagen content, and histopathological structures were evaluated in lung tissue. Results: Increased reactive oxygen species (ROS) production and oxidative stress after irradiation were down-regulated by luteolin treatment, demonstrating luteolin’s antioxidant and anti-inflammatory properties. Luteolin attenuated lung histopathological changes which represented by desquamation of bronchiolar epithelia with pre-bronchiolar leukocytic infiltrations, proliferation of pneumocytes type ІІ, emphysema and collapse induced by γ-rays. Conclusion: The current study found, for the first time, that luteolin has a protective effect on whole body γ-rays-induced early lung injury in rat model.</div> Luteolin, radio protector, radiation pneumonitis, γ-rays, rats. 193 198 http://ijrr.com/browse.php?a_code=A-10-1-1156&slc_lang=en&sid=1 S.S. Tawfik 7900319475328460026082 7900319475328460026082 No Health Radiation Research Department, National Centre for Radiation Research and Technology (NCRRT), P. O. Box 29, Nasr City, Cairo, Egypt. Egyptian Atomic Energy Authority, Nasr City, Cairo, Egypt A.A. El Kady elkadyah13@gmail.com 7900319475328460026083 7900319475328460026083 Yes Health Radiation Research Department, National Centre for Radiation Research and Technology (NCRRT), P. O. Box 29, Nasr City, Cairo, Egypt. Egyptian Atomic Energy Authority, Nasr City, Cairo, Egypt R.M. Ebrahim 7900319475328460026084 7900319475328460026084 No Health Radiation Research Department, National Centre for Radiation Research and Technology (NCRRT), P. O. Box 29, Nasr City, Cairo, Egypt. Egyptian Atomic Energy Authority, Nasr City, Cairo, Egypt W.A. El khouly 7900319475328460026085 7900319475328460026085 No